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Names | |
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IUPAC name
(1R,14S,15R)-25-Methyl-4,25-diazahexacyclo[13.7.3.01,14.03,12.05,10.017,22]pentacosa-3,5,7,9,11,17(22),18,20-octaene-14,20-diol | |
Identifiers | |
3D model (JSmol) |
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PubChem CID |
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Properties | |
C24H24N2O2 | |
Molar mass | 372.468 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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KNT-127 is an opioid drug selective for the delta opioid receptors.[1] It might be used as an analgesic and anxiolytic.
KNT-127 can be used as an analgesic. In mice, it was able to reverse inflammatory hyperalgesia.[2]
Multiple tests have shown KNT-127 to be able to reduce anxiety,[3] in a similar way to muscimol,[4]aGABAA agonist.
Chronic administration of KNT-127 created cross-tolerance to the analgesic effects of SNC-80, another opioid.
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