The show explored the story of star-crossed lovers Anurag and Prerna, various stages of their love and life as well as the lives of their children and grandchildren.
Anurag and Prerna fall in love with each other, only for fate to time and again separate them. Komolika and Rishabh Bajaj are vital catalysts in the story. Over a span of sixty years in the show, the story revolves around Anurag, Prerna, and their children Prem, Sneha, and eventually progressing to their grandchildren.
Prerna marries Rishabh Bajaj to protect the assets of Basu family.
Chapter 6
211 – 276
Bajaj's wife Menaka poses problems for Bajaj as they are not divorced yet.
Chapter 7
277 – 330
Bajaj disappears after his accident. Prerna and Anurag get engaged and married happily.
Chapter 8
331 – 374
Bajaj creates problems in Anurag and Prerna's paradise. He clicked intimate photos with Prerna in Pune by making her unconscious, later he used this photos to blackmail her with the help of Mr. Patel who was also involved in Prem's kidnapping.
Chapter 9
375 – 402
Prerna and Anurag's son Prem is abducted and dies due to the irresponsible behaviour of Prerna, who forgot Prem to pick up from school, before this she so many times ignored responsibility of Prem because of Kuki.
Chapter 10
403 – 441
Anurag and Prerna's marriage fell apart due to misunderstandings. Anurag marries Aparna leaving pregnant Prerna alone for her misdeed.
Chapter 11
442 – 472
Prerna is mad at Anurag and moves to Panchmeshwar with her daughter Sneha.
Chapter 12
473 – 511
After eight years, Sneha visits Anurag's house. Unwillingly and due to the pressurised situation Prerna decide to engage with Bajaj.
Chapter 13
512 – 572
Sneha fights leukaemia, Anurag and Prerna become closer due to her and have another child name Prem which left Bajaj to realize that Prerna only loves Anurag.
Chapter 14
573 – 623
Aparna's plot to murder Anurag.
Chapter 15
624 – 646
Prerna accused of Aparna's murder.
Chapter 16
647 – 685
Anurag not showing interest to get back Prerna, so she decides to marry Bajaj because of Sneha. Madhavi expose her pregnancy because of Bajaj but Bajaj refused to accept Madhavi as well as his unborn child with her.
Chapter 17
686 – 757
Generation Leap: Shravan avenges his mother Aparna's death.
Chapter 18
758 – 781
Anurag, Prerna and Bajaj meet with a fatal accident. Prerna suffers from amnesia, she forgets her last past years and only remembers her marriage with Anurag. Later she regains her memory, and accuses Anurag of conspiracy but realises her mistakes and apologizes to Anurag.
Chapter 19
782 – 833
Bajaj's past comes out. Tanisha is Bajaj's child with Madhavi, whom he refused to accept to marry Prerna.
Chapter 20
834 – 873
Yudi is actually Prem.
Chapter 21
874 – 928
Yudi's transformation. Prerna takes charge to change Prem.
Chapter 22
929 – 993
Mukti and Yudi grow closer. Sharad assaults Mukti.
Chapter 23
994 – 1022
An attempt to take Prerna's life.
Chapter 24
1023 – 1048
Anurag marries Sampada, Prerna takes the blame for Sneha's offence.
Chapter 25
1049 – 1069
After five years: Anurag-Sampada live happily by taking Prem and Sneha's responsibility. Bajaj destroys his business and leaves his family alone to suffer and cuts all relations with his family after hearing conversation of Prerna and Anurag which reveals the truth that she only loves Anurag. Although Anurag provides shelter to Bajaj's family. Prerna returns from jail.
Chapter 26
1070 – 1101
Prem is shattered by Mukti's death
Chapter 27
1102 – 1163
Prem is taken to Panchameshwar for treatment.
Chapter 28
1164 – 1202
Aparna's attempt to murder Prerna.
Chapter 29
1203 – 1250
Kasak falsely frames Shravan for her condition and manipulates Bajaj against Shravan, who believe Kasak and took idiotic step by vowing to destroy Shravan. Prerna shoots Anurag.
Chapter 30
1251 – 1300
Twenty years later, Prerna's granddaughter Prerna (P2) is the protagonist. Anurag returns as Pratham Mittal.
Chapter 31
1301 – 1358
Sampada confesses her crime. Prerna apologises to Anurag. Anurag exposes Bajaj that he is still alive.
Chapter 32
1359 – 1394
Anurag exposes Komolika's plan.
Chapter 33
1395 – 1423
Komolika points the gun at Anurag, but Prerna takes the bullet to save Anurag but both Anurag and Prerna die in each other's arms. Komolika falls off the cliff and dies. Prerna and Anurag unite in death. Prem writes a book: Kasautii Zindagii Kay on Anurag and Prerna's life. Mr. Bajaj left alone forever and two true love birds unite after death.
Tasneem Sheikh / Prerna Shah as Kajol Basu Sharma – Pranay and Yamini's daughter; Anirudh and Subroto's sister; Mahesh's wife (2001–2003)
Rushad Rana as Anirudh Basu – Pranay and Yamini's younger son; Subroto and Kajol's brother (2001–2002)
Hitesh Kriplani as Samay Basu – Sanjay and Geeta's elder son; Shulabh's brother (2001–2005)
Om Bhanushali as Shulabh Basu – Sanjay and Geeta's younger son; Samay's brother (2001–2005)
Nandita Thakur as Veena Sharma – Rajesh's wife; Shekhar, Prerna, Shivani, Mitali and Mahesh's mother; (2001–2008)
Manoj Pandey as Shekhar Sharma – Rajesh and Veena's elder son; Prerna, Shivani, Mitali and Mahesh's brother; Suman's husband (2001–2004)
Kusumit Sana as Shivani Sharma – Rajesh and Veena's second daughter; Prerna, Shekhar, Mitali and Mahesh's sister; Subroto's former wife (2001–2003)
Kishwer Merchant as Mitali Sharma – Rajesh and Veena's youngest daughter; Prerna, Shekhar, Shivani and Mahesh's sister (2001–2004)
Shivani Gosain as Suman Sharma – Shekhar's wife (2001–2004)
Mahesh Pandey as Mahesh Sharma – Rajesh and Veena's younger son; Prerna, Shekhar, Shivani, and Mitali's brother; Kajol's husband (2001–2004)
Anand Suryavanshi / Vivek Mushran / Nasir Khan as Vineet Khanna – Anurag's business partner and best friend; Madhavi's husband; Tanisha's adoptive father (2001–2006)
Poonam Joshi as Jyoti – Prerna's best friend (2001–2002)/(2003–2004)
Sikandar Kharbanda as Indraneel Sengupta – Chaini's youngest son; Anupam and Praveen's brother; Komolika's spy (2002–2008)
Himani Shivpuri as Chaini Sengupta – Praveen, Anupam and Indraneel's mother; (2002–2003)
Mini Ribeiro as Uma Majumdar – Komolika's mother (2001–2002)
Prashant Bhatt as Akash Dasgupta – Komolika's former husband (2002)
Ruby Bhatia as Menaka Bose – Madhavi's sister; Rishabh's-wife; Tushar, Vishakha and Kukki's mother; (2002–2003) (Dead)
Vishal Sabnani as Tushar Bajaj – Rishabh and Menaka's son; Prerna's adopted son; Vishakha and Kukki's brother; Tanisha and Kasak's half-brother; Doris's husband; Tara, Jwala, Gargi and Kanishta's father (2002–2008)
Suzanne Bernert as Doris Bajaj – Tushar's wife; Tara, Jwala, Gargi and Kanishta's mother (2006–2008)
Tarana Raja / Preeti Puri / Amita Chandekar as Vishakha Bajaj – Rishabh and Menaka's elder daughter; Tushar and Kukki's sister; Tanisha and Kasak's half-sister; Tanvi's mother (2002–2007)
Mansi Parekh / Garima Bhatnagar as Kokila 'Kukki' Bajaj – Rishabh and Menaka's younger daughter; Tushar and Vishakha's sister; Tanisha and Kasak's half-sister; Tanvi's adoptive mother (2004–2007)
Swapnali Kulkarni as Child Kokila "Kukki" Bajaj (2002–2003)
Unknown as Prem Basu – Anurag and Prerna's elder son; Sneha and Jr. Prem's brother; Kasak's half-brother (2002–2003) (Dead)
Jennifer Winget as Sneha Basu Gill – Anurag and Prerna's daughter; Bajaj's adopted daughter; Prem and Jr. Prem's sister; Kasak's half-sister; Sharad's ex-wife; Omi's wife; Jr. Prerna's mother (2005–2007)
Karanvir Bohra / Vikas Sethi as Jr. Prem Basu – Anurag and Prerna's younger son; Prem and Sneha's brother; Kasak's half-brother; Devki's husband; Palchin's widow; Dhara and Rudraksh's father (2005–2008)
In November 2007, Kasautii was confirmed going off-air in January 2008.[12] However it ended on 28 February 2008 for which Kapoor stated, "I won't deny that the TRPs of Kasautii… had gone down quite a bit and moreover, I didn't have a story to tell."[13]
A reboot of the show, also titled Kasautii Zindagii Kay, was aired on Star Plus from 25 September 2018 to 3 October 2020 for two years which did not sustain expected ratings unlike this series.[14][15] This reboot has been remade in Kannada language on Star Suvarna titled Premloka.[16]
Rediff.com stated, "One nice thing about Kasauti... is that all characters in the serial are very strong. Be it the protagonists or antagonists, every character stands on firm ground."[17]
It began with an average ratings of 4.44 while in 2002, 2003, 2004 it grows to an average TRP of 7.51, 8.83 and 9.14 respectively.[24] Kasautii garnering 9.9 TVR as on 18 November 2003 at third position.[25] The crossover episode between Des Mein Niklla Hoga Chand and Kasautii during October 2003 garnered 14+ TVR.[26]
While in 2005, it maintained its third position with 10.93 TVR while the following year it dropped 8.78 TVR despite maintaining its position.[27]
In second week of January 2007, Kasautii continued to be third with a declined rating of 5.6 TVR.[28][29]
Being one of the top-rated Indian television series maintaining its position in top 10 programs until 2008, it dropped to eleventh position in January 2008 after which it was soon cancelled.[30]
The Kasautii Zindagii Kay soundtrack has recorded more than hundred tracks during its airing from 2001 to 2008 and won several awards. The tracks include versions of Bollywood hit songs Kya Pyaar Karoge Mujhse,[31]Ajeeb Dastan Hai Yeh,[32]Hum Bewafa Hargiz Na Thay,[33]Kal Ho Naa Ho, Jiyen To Jiyen Kaisy[34] and Do Ajnabi Kidar Ja Rahy Hain.