In 1942 Little wrote to John Lucien Keith, chairman of the Colonial Office's Advisory Committee on the Welfare of Colonial Peoples in the United Kingdom, about what he regarded as the justifiable concerns of the representatives of British colonials in the United Kingdom as regards the introduction of American-style racial segregation, reminding Keith that news of incidents of racial clashes and discrimination was very quickly transmitted to the colonies.[2][3]
Little studied for his Ph.D. at the London School of Economics, and his thesis, which was published in 1948 as Negroes in Britain, was a study of the Black and minority ethnic communities of Cardiff.[4] The African-American sociologist St. Clair Drake worked with the Black community of Cardiff drafting a response, in which the local community said they "distrust people who survey us and study us, who write about us and publicize us, and who try to reform and lead us."[2]
Little went on to complete The Mende of Sierra Leone (published in 1951). When Ralph Piddington moved on from the University of Edinburgh, he encouraged Little to move there to establish a new Social Sciences Research Unit.[5] Appointed as Reader in Social Anthropology, Little was the head of the Department of Social Anthropology, and was appointed a professor in 1965.