He was the fourth (4th) son of Kabaka Ndawula Nsobya, the nineteenth (19th) Kabaka of Buganda. His mother was Nakikulwe Namirembe, the third (3rd) of his father's seven (7) wives. He ascended the throne after the death of his elder brother, Kabaka Kagulu Tebukywereke. He established his capital at Kibibi.[1] He is remembered as a malevolent ruler.[1]
He is recorded to have fathered at least nine children:
Prince (Omulangira) Madangu, whose mother was Nakabugo
Princess (Omumbejja) Mpalikitenda, whose mother was Nabiddo
Prince (Omulangira) Maganda, whose mother was Nakabugo
Prince (Omulangira) Ggobango, whose mother was Nakabugo
Prince (Omulangira) Segaamweenge, whose mother was Nakabugo
Princess (Omumbejja) Zansanze, whose mother was Nakabugo
Princess (Omumbejja) Nabaloga, whose mother was Nakabugo
Prince (Omulangira) Ngobe, whose mother was Namatovu
Prince (Omulangira) Gomottoka, whose mother was Namatovu - He issued sons 1. Prince (Omulangira) Mpadwa kussambiza 2. Prince (Omulangira) Kolobola 3. Prince (Omulangira) Genza 4. Prince (Omulangira) Kisala Ggolooba 5. Prince (Omulangira) Luwarira 6. Prince (Omulangira) Kimu Other sons were sold into slavery by reigning kings to deter them from claiming the thrown.
Kabaka Kikulwe was murdered by his elder half-brother, Prince Mawanda Sebanakitta, who seized the throne around 1738. Ssekabaka Kikulwe is buried at Kaliiti, Busiro.[2]