Krippendorff started to work as an engineer and during the last year of his graduate study of design he was a research assistant at the Institute for Visual Perception at the Ulm School of Design. In 1961 he came to the United States with a two-year Ford International Fellowship, first to Princeton University but completing his second graduate education at the University of Illinois at Urbana-Champaign. In 1964, he joined the Annenberg School for Communication at the University of Pennsylvania.[6]
He is or was a member of the editorial boards of multiple academic journals, such as Communication and Information Science, Communication Research, Constructivist Foundations, Cybernetics & Human Knowing, International Journal of Cultural Studies and the Journal of Communication.[6]
In 1971, he was awarded an honorary MA from the University of Pennsylvania. In the same year, he received an award for "On Generating Data in Communication Research" as the most outstanding contribution to The Journal of Communication, published in 1970. In 1979, he became a Fellow of the Netherlands Institute for Advanced Study in the Humanities and Social Sciences. He was elected a fellow of the American Association for the Advancement of Science (AAAS) in 1982, a fellow of the International Communication Association (ICA) in 1985, and a fellow of the Japanese Society for Science and Design Studies in 1998.
In 1998, graduate students named him as the teacher of the best doctoral course taken at the University of Pennsylvania. In 2000, he became the Gregory Bateson professor for Cybernetics, Language, and Culture at the Annenberg School for Communication. In 2001, he was awarded the Norbert Wiener Medal in Cybernetics in gold by the American Society for Cybernetics. Also in 2001, he received the ICA Fellows Book Award for his influential text Content Analysis, An Introduction to Its Methodology. In 2004, he received the Norbert Wiener/Hermann Schmidt Prize from the German Society for Cybernetics and the German Society for Pedagogy and Information at the University of Vienna.[6]
Krippendorff has published widely on cybernetics and systems theory, methodology in the social sciences, human communication, conversation, and discourse.[9] Among his major works are the following:
1967, An Examination of Content Analysis: A Proposal for a Framework and an Information Calculus for Message Analytic Situations, Ph.D. Dissertation, Urbana: University of Illinois, 400 pp.
1970, "Bivariate agreement coefficients for reliability of data", in E. F. Borgatta: Sociological Methodology. San Francisco: Jossey-Bass, 139–150.
1980, Content Analysis; An Introduction to its Methodology, Beverly Hills, CA: Sage, 188 pp. (Translated into Italian, Japanese, Spanish, and Hungarian)