Contents

LAIR1

Protein-coding gene in the species Homo sapiens

LAIR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KGR, 3RP1
Identifiers
Aliases	LAIR1, CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1
External IDs	OMIM: 602992; MGI: 105492; HomoloGene: 48097; GeneCards: LAIR1; OMA:LAIR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,351,384 bp[1] End 54,370,558 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 2.31 cM Start 4,006,401 bp[2] End 4,066,203 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix monocyte spleen blood lymph node bone marrow right lung placenta upper lobe of left lung Top expressed in granulocyte spleen stroma of bone marrow zygote mesenteric lymph nodes secondary oocyte lumbar subsegment of spinal cord blood supraoptic nucleus thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane specific granule membrane tertiary granule membrane Biological process adaptive immune response regulation of immune response immune system process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3903 52855 Ensembl ENSG00000276053 ENSG00000276163 ENSG00000278154 ENSG00000274110 ENSG00000167613 n/a ENSMUSG00000055541 UniProt Q6GTX8 Q8BG84 RefSeq (mRNA) NM_001289023 NM_001289025 NM_001289026 NM_001289027 NM_002287 NM_021706 NM_021708 NM_001113474 NM_178611 NM_001302675 NM_001302676 NM_001302677 NM_001302681 NM_001302682 NM_001302683 RefSeq (protein) NP_001275952 NP_001275954 NP_001275955 NP_001275956 NP_002278 NP_068352 NP_001106945 NP_001289604 NP_001289605 NP_001289606 NP_001289610 NP_001289611 NP_001289612 NP_848726 Location (UCSC) Chr 19: 54.35 – 54.37 Mb Chr 7: 4.01 – 4.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.^[5][6] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

Function[edit]

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.^[7] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.^[6]

Interactions[edit]

LAIR1 has been shown to interact with PTPN11^[5][8] and PTPN6.^{[5][8][9][10][11]}

References[edit]

Further reading[edit]

External links[edit]

• LAIR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q6GTX8 (Leukocyte-associated immunoglobulin-like receptor 1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This immunology article is a stub. You can help Wikipedia by expanding it.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.