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LILRB2

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LILRB2

Identifiers

Aliases

LILRB2, ILT4, MIR10, LIR2, MIR-10, LIR-2, leukocyte immunoglobulin like receptor B2, ILT-4, CD85D

External IDs

OMIM: 604815; HomoloGene: 136797; GeneCards: LILRB2; OMA:LILRB2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.42	Start	54,273,812 bp^[1]
Band	19q13.42	End	54,281,184 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

granulocyte

blood

spleen

appendix

bone marrow

bone marrow cells

right lung

upper lobe of left lung

testicle

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


10288


n/a

Ensembl

ENSG00000274513 ENSG00000275463 ENSG00000131042 ENSG00000276146 ENSG00000277751
n/a


n/a

UniProt


A2IXV5


n/a

RefSeq (mRNA)

NM_001080978 NM_001278403 NM_001278404 NM_001278405 NM_001278406
NM_005874


n/a

RefSeq (protein)

NP_001074447 NP_001265332 NP_001265333 NP_001265334 NP_001265335
NP_005865


n/a

Location (UCSC)

Chr 19: 54.27 – 54.28 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.^[3]^[4]^[5]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury.^[6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairmentinAlzheimer's disease.^[7]^[8]

Interactions

[edit]

LILRB2 has been shown to interact with PTPN6.^[9]^[10]

References

[edit]

^ ^a ^b ^c ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 GRCh38: Ensembl release 89: ENSG00000274513, ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, et al. (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–1751. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.

^ Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–665. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.

^ ^a ^b "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".

^ Mi YJ, Chen H, Guo N, Sun MY, Zhao ZH, Gao XC, et al. (2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging Neuroscience. 9: 199. doi:10.3389/fnagi.2017.00199. PMC 5476690. PMID 28676756.

^ Lao K, Zhang R, Dai Y, Luan J, Guo N, Xu X, et al. (July 2021). "Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease". Molecular and Cellular Neurosciences. 114: 103630. doi:10.1016/j.mcn.2021.103630. PMID 34029694. S2CID 235203153.

^ Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, et al. (September 2013). "Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model". Science. 341 (6152): 1399–1404. Bibcode:2013Sci...341.1399K. doi:10.1126/science.1242077. PMC 3853120. PMID 24052308.

^ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (November 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–3434. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.

^ Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. (April 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology. 160 (7): 3096–3100. doi:10.4049/jimmunol.160.7.3096. PMID 9531263. S2CID 255370078.

Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO (August 1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Current Biology. 7 (8): 615–618. Bibcode:1997CBio....7..615W. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559. S2CID 14484039.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, et al. (December 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–1818. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.

Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. (April 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology. 160 (7): 3096–3100. doi:10.4049/jimmunol.160.7.3096. PMID 9531263. S2CID 255370078.

Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–5196. doi:10.4049/jimmunol.159.11.5192. PMID 9548455. S2CID 36907307.

Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (November 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–3434. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.

Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, et al. (April 1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells". The Journal of Experimental Medicine. 189 (7): 1149–1156. doi:10.1084/jem.189.7.1149. PMC 2193000. PMID 10190906.

Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, et al. (December 2000). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". European Journal of Immunology. 30 (12): 3552–3561. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396. S2CID 42462661.

Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–278. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.

Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature Immunology. 3 (3): 237–243. doi:10.1038/ni760. PMID 11875462. S2CID 35400503.

Willcox BE, Thomas LM, Chapman TL, Heikema AP, West AP, Bjorkman PJ (October 2002). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Structural Biology. 2: 6. doi:10.1186/1472-6807-2-6. PMC 130215. PMID 12390682.

Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, et al. (July 2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 8856–8861. Bibcode:2003PNAS..100.8856S. doi:10.1073/pnas.1431057100. PMC 166403. PMID 12853576.

Nakajima H, Asai A, Okada A, Ping L, Hamajima F, Sata T, et al. (December 2003). "Transcriptional regulation of ILT family receptors". Journal of Immunology. 171 (12): 6611–6620. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.

Papanikolaou NA, Vasilescu ER, Suciu-Foca N (July 2004). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Human Immunology. 65 (7): 700–705. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.

v t e PDB gallery
2dyp: Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G 2gw5: Crystal Structure of LIR-2 (ILT4) at 1.8 : differences from LIR-1 (ILT2) in regions implicated in the binding of the Cytomegalovirus class I MHC homolog UL18

External links

[edit]

LILRB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
LILRB2 human gene location in the UCSC Genome Browser.
LILRB2 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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