LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.[5][6]
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNAorRNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.[7]
LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.[7]
LIMK1 has been shown to interact with:
