Hewitson's research has primarily focused on embryo metabolism, cytoskeletal dynamics, centrosome abnormalities during fertilization, assisted reproductive technology (ART) in non-human primates and infant primate neonatal development.[6] More recently, Hewitson's research has focused on understanding genetic and environmental influences that lead to adverse pregnancy outcomes, with special emphasis on autism spectrum disorders (ASD).[4][6] Her research has been funded through the National Institutes of Health,[7] as well as private foundations.[4][6][7]
Hewitson's work on primate fertilization examined the role of the centrosome during assisted reproduction and identified unique check-points during the first cell cycle.[7] She also explored the safety of new methods of assisted reproduction by producing infant primates by ART to follow their early development and behavior (see Selected Publications).
Hewitson's more recent research has focused on the study of genetic versus epigenetic (environmental) causes of neurodevelopmental disorders.[4][6] While at the University of Pittsburgh she researched the possible connection between pediatric vaccines and behavior and presented some of this research at the International Meeting for Autism Research (IMFAR) in 2008[8] and the Neurobehavioral Teratology Society (NBTS) meeting in 2011.[9] She is now continuing this research with colleagues at the WaNPRC.[10][11] Hewitson is also collaborating with colleagues at the University of Texas Southwestern Medical School to identify blood biomarkers for autism.[2] With funding from the Simons Foundation Autism Research Initiative[12] and the Department of Defense Congressionally Directed Medical Research Program (CDMRP),[13]
Hewitson, L.C., Leese, H.J. (1993) Energy metabolism of the trophectoderm and inner cell mass of the mouse blastocyst. J Exp Zool. 267:337-343.
Hewitson, L.C., Martin, K.L., Leese, H.J. (1996) Effects of metabolic inhibitors on mouse preimplantation embryo development and the energy metabolism of isolated inner cell masses. Mol Reprod Dev. 43:323-330.
Hewitson, L., Simerly, C., Tengowski, M.W, Sutovsky, P., Navara, C.S., Haavisto, A.J. and Schatten, G. (1996) Microtubule and chromatin configurations during rhesus intracytoplasmic sperm injection: Successes and Failures. Biol. Reprod. 55:271–280.
Hewitson, L., Haavisto A, Simerly C, Jones J and Schatten G (1997) Microtubule organization and chromatin configurations in hamster oocytes during fertilization, parthenogenetic activation and after insemination with human sperm. Biol.Reprod. 57: 967–975.
Hewitson L, Takahashi D, Dominko T, Simerly C, and Schatten G. (1998) Fertilization and embryo development to blastocysts after intracytoplasmic sperm injection in the rhesus monkey. Hum Reprod 13:3449-3455.
Schatten G, Hewitson L, Simerly C, Sutovsky P and Huszar G. (1998) Cell and Molecular Biological Challenges of ICSI: A.R.T. Before Science? J Law Med Ethics 26:29-37.
Hewitson, L, Dominko, T, Takahashi, D, Ramalho-Santos, J, Sutovsky, P, Fanton, J, Jacob, D, Monteith, D, Neuringer, M, Battaglia, D, Simerly, C, and G. Schatten. (1999) Births of ICSI monkeys: unique checkpoints during the first cell cycle of fertilization. Nature Medicine 5:431-433.
Ramalho-Santos, J., Moreno, R.D., Sutovsky, P., Chan, A.Q.., Hewitson, L., Wessel G.M., Simerly C.R., and Schatten, G. (2000) SNAREs in mammalian sperm: possible implications for fertilization. Dev Bio 223:54-69.
Hewitson, L., Martinovich, C., Simerly, C., Takahashi, D., Schatten, G. (2002) Intracytoplasmic injection of rhesus testicular sperm (TESE-ICSI) and elongated spermatids (ELSI) results in healthy offspring. Fertil Steril. 77:794-801.
Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.Y., Compton, D., Hewitson, L., and Schatten, G. (2000) Molecular Correlates of Primate Nuclear Transfer Failures. Science 300: 297–299.
Dettmer, AM, Houser, LA, Ruppenthal, GC, Capuano, S, Hewitson, L. (2007) Growth and developmental outcomes of three high-risk infant rhesus macaques (Macaca mulatta). Am J Primatol. 69: 503–518.
Hewitson, L., Lopresti, B., Mason, N.S, Stott, C. and Tomko, J. (2010) Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiologiae Exp 70: 147–164.
Bharathi S. Gadad, Laura Hewitson, Keith A. Young, and Dwight C. German, "Neuropathology and Animal Models of Autism: Genetic and Environmental Factors," Autism Research and Treatment, vol. 2013, Article ID 731935, 12 pages, 2013. doi:10.1155/2013/731935
Schutte C, Hewitson L. Relationship between Stereotyped Behaviors and Restricted Interests (SBRIs) measured on the Autism Diagnostic Observation Schedule (ADOS) and diagnostic results. Open Access Autism 2014 Aug 11;2(2):15.
Curtis B, Liberato N, Rulien M, Morrisroe K, Kenney C, Yutuc V, Ferrier C, Marti CN, Mandell D, Burbacher TM, Sackett GP, Hewitson L. Examination of the Safety of Pediatric Vaccine Schedules in a Non-Human Primate Model: Assessments of Neurodevelopment, Learning, and Social Behavior. Environmental Health Perspectives, Feb 18, 2015
^ abcHewitson L, et al. (April 1999). "Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys". Nat Med. 5 (4): 431–3. doi:10.1038/7430. PMID10202934. S2CID6564806.
^Hewitson L, et al. (2011). "Discrimination Reversal Learning in Infant Primates Exposed to Low-Dose Thimerosal: A Pilot Study". Neurotoxicology and Teratology. 33 (4): 501. doi:10.1016/j.ntt.2011.05.036.
