Contents

Levocabastine

Chemical compound

Levocabastine

Clinical data
Trade names	Livostin
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: B3
Routes of administration	Ophthalmic, intranasal[1]
ATC code	R01AC02 (WHO) S01GX02 (WHO)
Legal status
Legal status	US: ℞-only[2] In general: ℞ (Prescription only)
Identifiers
IUPAC name (3S,4R)-1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid
CAS Number	79516-68-0 Y
PubChem CID	54385
IUPHAR/BPS	1586
DrugBank	DB01106 Y
ChemSpider	16736421 Y
UNII	H68BP06S81
KEGG	D08117 Y
ChEMBL	ChEMBL1201312 N
CompTox Dashboard (EPA)	DTXSID1048548
Chemical and physical data
Formula	C26H29FN2O2
Molar mass	420.528 g·mol−1
3D model (JSmol)	Interactive image
SMILES Fc1ccc(cc1)[C@]2(CC[C@@H](CC2)N3CC[C@@]([C@H](C)C3)(c4ccccc4)C(O)=O)C#N
InChI InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1 Y Key:ZCGOMHNNNFPNMX-KYTRFIICSA-N Y
NY (what is this?)  (verify)

Levocabastine (trade name Livostin or Livocab, depending on the region) is a selective second-generation H₁ receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.^[3]

As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS₂, and was the first drug used to characterise the different neurotensin subtypes.^[4][5] This has made it a useful tool for the study of this receptor.^{[6][7][8][9][10]}

The pharmaceutical drug Bilina is a combination of Levocabastine, benzalkonium chloride, and other components and is typically used in a 0.5 mg/ml suspension as eye-drops, dispensed in 4ml bottles for the treatment of allergic conjunctivitis or similar allergic ocular conditions.^[11]

References[edit]

External links[edit]

• "Levocabastine". Drug Information Portal. U.S. National Library of Medicine.
• "Levocabastine hydrochloride". Drug Information Portal. U.S. National Library of Medicine.

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