Contents

Lipoblastomatosis

Benign lipoblastomatosis is a tumor consisting of fetal-embryonal adipocytes, frequently confused with a liposarcoma, affecting exclusively infants and young children, with approximately 90% of cases occurring before 3 years of age.^{[2][3]: 626} The term lipoblastomatosis was first used by Vellios et al. in 1958, at which point the tumor became generally accepted as a distinctive entity.^[4][5] Today Diffuse lipoblastoma is the preferred term for lipoblastomatosis.^[6][7] The tumor is rare, accounting for less than 1% of all childhood neoplasm,^[8] and it has been found to be more common in males than females.^[9][8] It often presents as an asymptomatic rapidly enlarging mass, occurring more often in the soft tissues of the extremities.^[8][9]

Although they have also been reported in the head and neck, shoulder, groin, axilla, back, and abdominal cavity, these tumors typically manifest in the extremities.^[10] Although it is normally painless, it may cause symptoms such as vomiting, stomach pain, paralysis, or fecalorurinary incontinence, depending on where the mass is anatomically.^[11][12]

Lipoblastomatosis most likely results from new adipose tissue lobules and lipoblasts proliferating throughout the neonatal period.^[10]

Although imaging modalities like magnetic resonance imaging (MRI) and computed tomography (CT) can be useful, histology confirmation is necessary for an accurate diagnosis.^[10]

Prompt surgical resection is the advised course of treatment for lipoblastomatosis, particularly if the mass is close to any important organs.^[10]

• Myxoid lipoblastoma
• List of cutaneous conditions

• Hicks, John; Dilley, Anthony; Patel, Dimple; Barrish, James; Zhu, Shen-Hua; Brandt, Mary (2001). "Lipoblastoma and Lipoblastomatosis in Infancy and Childhood: Histopathologic, Ultrastructural, and Cytogenetic Features". Ultrastructural Pathology. 25 (4): 321–333. doi:10.1080/019131201753136359. ISSN 0191-3123. PMID 11577778.
• Dutton, Jonathan J.; Escaravage, George K.; Fowler, Amy M.; Wright, John D. (2011). "Lipoblastomatosis: Case Report and Review of the Literature". Ophthalmic Plastic & Reconstructive Surgery. 27 (6): 417–421. doi:10.1097/IOP.0b013e318221118c. ISSN 0740-9303. PMID 21743369.

• Pathology Outlines
• VisualDx