This is a list of Indiana State Sycamores football players in the NFL Draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| = Pro Bowler | |
| = Hall of Famer |
Source:[1]
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1967 | 7 | 10 | 169 | John Truitt | Chicago Bears | WR |
| 1970 | 10 | 10 | 244 | Jim Brumfield | New Orleans Saints | RB |
| 1973 | 12 | 24 | 310 | Willie Lee | Pittsburgh Steelers | RB |
| 1975 | 17 | 20 | 436 | Ken Monroe | St. Louis Cardinals | RB |
| 1976 | 13 | 12 | 359 | Larry Brumfield | San Francisco 49ers | DT |
| 1980 | 6 | 27 | 165 | Tunch Ilkin | Pittsburgh Steelers | T |
| 1982 | 6 | 11 | 150 | Craig Shaffer | St. Louis Cardinals | LB |
| 1984 | 7 | 25 | 193 | Ed Martin | Dallas Cowboys | LB |
| 1985 | 2 | 11 | 39 | Wayne Davis | San Diego Chargers | CB |
| 8 | 21 | 217 | Steve Buxton | Chicago Bears | OT | |
| 1986 | 2 | 24 | 54 | Vencie Glenn | New England Patriots | S |
| 1987 | 10 | 1 | 252 | Mike Simmonds | Tampa Bay Buccaneers | G |
| 10 | 16 | 267 | Bob Riley | Minnesota Vikings | T | |
| 1992 | 12 | 15 | 323 | Charles Swann | New York Giants | WR |
| 1996 | 7 | 27 | 237 | Dan Brandenburg | Buffalo Bills | DE |
Note: No drafts held before 1920
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 1985 | Rick Dwenger | FB | Indianapolis Colts | — |
| 1994 | John Bock | C | Buffalo Bills | — |
| 2017 | Robert Tonyan | TE | Detroit Lions | — |
| 2020 | Dominique Dafney | TE | Indianapolis Colts | — |
| Jonas Griffith | LB | San Francisco 49ers | — |
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