The Billboard Regional Mexican Songs is a subchart of the Latin Airplay chart that ranks the best-performing songs on Regional Mexican radio stations in the United States. Published weekly by Billboard magazine, it ranks the "most popular regional Mexican songs, ranked by radio airplay audience impressions as measured by Nielsen Music."[1]
| † | Indicates best-performing song of 2021[2] |
| Issue date | Song | Artist(s) | Ref. |
|---|---|---|---|
| January 2 | "Te Volveria A Elegir" † | Calibre 50 | [3] |
| January 9 | [4] | ||
| January 16 | [5] | ||
| January 23 | [6] | ||
| January 30 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar | [7] |
| February 6 | [8] | ||
| February 13 | [9] | ||
| February 20 | [10] | ||
| February 27 | [11] | ||
| March 6 | "Saludos A Mi Ex" | Edwin Luna and La Trakalosa de Monterrey | [12] |
| March 13 | "Yo Todo Lo Doy" | Alfredo Olivas | [13] |
| March 20 | "Saludos A Mi Ex" | Edwin Luna and La Trakalosa de Monterrey | [14] |
| March 27 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga | [15] |
| April 3 | [16] | ||
| April 10 | [17] | ||
| April 17 | [18] | ||
| April 24 | "Duele" | Alejandro Fernández and Christian Nodal | [19] |
| May 1 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga | [20] |
| May 8 | "Vamos Bien" | Calibre 50 | [21] |
| May 15 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga | [22] |
| May 22 | "2 Veces" | Los Plebes del Rancho de Ariel Camacho and Christian Nodal | [23] |
| May 29 | [24] | ||
| June 5 | [25] | ||
| June 12 | [26] | ||
| June 19 | "Mi Primer Derrota" | La Arrolladora Banda el Limon de Rene Camacho | [27] |
| June 26 | "Te Encontré" | Ulices Chaidez / Eslabon Armado | [28] |
| July 3 | "Calzones Finos" | Los Nuevos Federales | [29] |
| July 10 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda | [30] |
| July 17 | "Sin Miedo Al Exito" | Banda Los Sebastianes de Saul Plata | [31] |
| July 24 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda | [32] |
| July 31 | [33] | ||
| August 7 | [34] | ||
| August 14 | "Soy Buen Amigo" | El Fantasma | [35] |
| August 21 | "A La Antiguita" | Calibre 50 | [36] |
| August 28 | [37] | ||
| September 4 | [38] | ||
| September 11 | "El Toxico" | Grupo Firme and Carin Leon | [39] |
| September 18 | [40] | ||
| September 25 | "Tus Desprecios" | Pepe Aguilar and El Fantasma | [41] |
| October 2 | "Se Veia Venir" | Marco Antonio Solís | [42] |
| October 9 | "Que Tienen Tus Palabras?" | Banda El Recodo de Cruz Lizarraga | [43] |
| October 16 | "Tranquilito" | Gerardo Ortiz | [44] |
| October 23 | [45] | ||
| October 30 | "Ya Supérame (En Vivo Desde Culiacán, Sinaloa)" | Grupo Firme | [46] |
| November 6 | [47] | ||
| November 13 | [48] | ||
| November 20 | "Yo Soy Rico" | Los Dos Carnales | [49] |
| November 27 | "La Sinvergüenza" | Christian Nodal and Banda MS | [50] |
| December 4 | [51] | ||
| December 11 | "Como Te Olvido" | La Arrolladora Banda el Limon de Rene Camacho | [52] |
| December 18 | [53] | ||
| December 25 | "Ya Solo Eres Mi Ex" | La Adictiva | [54] |
