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(Top) 1 Footnotes 2 See also 3 References

List of target antigens in pemphigus

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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Target antigens for the different pemphigus variants
Pemphigus variant	Antibody isotype	Antigen	Molecular weight (KDa)
Mucosal pemphigus vulgaris	IgG	Desmoglein 3	130
Mucocutaneous pemphigus vulgaris	IgG	Desmoglein 3 Desmoglein 1	130 160
Pemphigus foliaceus	IgG	Desmoglein 1	160
Paraneoplastic pemphigus	IgG	Desmoglein 3 Desmoglein 1 BPAG1^{[nb 1]} Plectin Desmoplakin I^{[nb 2]} Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1	130 160 230 500 250 210 210 190 170
Drug-induced pemphigus	IgG	Desmoglein 3 Desmoglein 1	130 160
Subcorneal pustular dermatosis type of IgA pemphigus	IgA1	Desmocollin 1	110/100
Intraepidermal neutrophilic type of IgA pemphigus	IgA1	Unknown
Pemphigus erythematosus (Senear–Usher syndrome)^{[nb 3]}	IgG	Desmoglein 1	160
Fogo selvagem	IgG	Desmoglein 1	160
Pemphigus vegetans	IgG	Desmoglein 3	130
Pemphigus vegetans of Hallopeau^{[nb 4]}	IgG	Desmoglein 3	130
Pemphigus vegetans of Neumann^{[nb 4]}	IgG	Desmoglein 3	130
Pemphigus herpetiformis	IgG	Desmoglein 3 Desmoglein 1	130 160

Footnotes

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^ Notably not BPAG2

^ Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome

^ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.

^ ^a ^b Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.

References

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Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

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