Lori Passmore
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Lori Anne Passmore
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| Nationality | Canadian/British |
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| Thesis | Structural and functional studies of the anaphase promoting complex (APC) (2003) |
| Doctoral advisor | David Barford |
| Other academic advisors | Venki Ramakrishnan Richard Henderson |
| Website | www2 |
Lori Anne Passmore FRS is a Canadian/British cryo electron microscopist and structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge.[3][4] She is known for her work on multiprotein complexes involved in gene expression[5][6][7] and development of new supports for cryo-EM.[8]
Lori Passmore graduated from the University of British Columbia, Canada in 1999.[9] She obtained a PhD in 2003 from University of London for research supervised by David Barford at the Institute of Cancer Research. She performed in vitro biochemical characterisation of the activity of the anaphase-promoting complex (APC)[10] and used cryo-EM to study the APC structure.[2][11]
Passmore worked as a postdoctoral researcher at the MRC-LMB. She worked with Venki Ramakrishnan and Richard Henderson, using cryo-EM to determine the structure of the eukaryotic ribosome bound to initiation factors.[12] Passmore became a group leader at the MRC-LMB in 2009. Her group uses in vitro reconstitution, biochemical assays and cryo-EM to understand the function of multiprotein complexes that regulate gene expression at the level of mRNA.[5][6][7] Her group has developed new sample grids for cryo-EM that reduce specimen movement during imaging.[8] In collaboration with Ketan J. Patel, Passmore is also actively studying the molecular mechanisms underlying Fanconi anemia.[13][14]
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