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Contents

   



(Top)
  


1 Pharmacokinetics  




2 Mechanism of action  




3 Interactions  




4 Brand names  




5 References  













Loxoprofen






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From Wikipedia, the free encyclopedia
  

Loxoprofen
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, transdermal
ATC code
Legal status
Legal status
  • JP: Class 1 OTC
    BR: Red Stripe (Rx only)
Pharmacokinetic data
Protein binding97%
MetabolismLiver glucuronidation
Elimination half-life75 minutes
ExcretionKidney
Identifiers

  • (RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid

CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H18O3
Molar mass246.306 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture

  • O=C2C(Cc1ccc(cc1)C(C(=O)O)C)CCC2

  • InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) checkY

  • Key:YMBXTVYHTMGZDW-UHFFFAOYSA-N checkY

 ☒NcheckY (what is this?)  (verify)

Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006;[1] medicated tape and gel formulations followed in 2008 and 2010.

It was patented in 1977 and approved for medical use in 1986.[2]

Pharmacokinetics[edit]

Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action[edit]

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Interactions[edit]

Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures.[3] It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.[3]

Brand names[edit]

It is marketed in Brazil, Mexico, China and JapanbySankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin; in Argentina as Oxeno; in India as Loxomac; in Thailand as Japrolox; and in Saudi Arabia as Roxonin and Roxonin Tape.

Ageneric drug is marketed in Brazil by Aché as Oxotron. In Japan, two fixed dose combinations are available: Loxonin S Plus, with magnesium oxide, and Loxonin S Premium, with apronal, caffeine, and aluminium magnesium silicate.

References[edit]

  1. ^ Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.
  • ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 521. ISBN 9783527607495.
  • ^ a b "LOXONIN - Bula do Medicamento [Label Information]" (in Portuguese). Centralx. 2007. Retrieved 2007-04-19.
    • Wikimedia Commons has media related to Loxoprofen.

    Retrieved from "https://en.wikipedia.org/w/index.php?title=Loxoprofen&oldid=1234029745"
    Categories: 
    ●Nonsteroidal anti-inflammatory drugs
     ●Prodrugs
     ●Cycloalkanones
     ●Propionic acids
     ●Daiichi Sankyo
     ●Cyclopentanes
     Hidden categories: 
    ●CS1 Portuguese-language sources (pt)
     ●Articles with short description
     ●Short description is different from Wikidata
     ●Drugs with non-standard legal status
     ●Articles with changed CASNo identifier
     ●Articles with changed EBI identifier
     ●Drugboxes which contain changes to verified fields
     ●Drugboxes which contain changes to watched fields
     ●Commons category link from Wikidata
      


    ●This page was last edited on 12 July 2024, at 06:22 (UTC).
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