Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[5][6][7]
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[7]
Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.
MAML1 has been shown to interact with EP300[8][9] and NOTCH1.[5][10]
PDB gallery
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2f8x: Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
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