Contents

MAP1A

Protein-coding gene in the species Homo sapiens

MAP1A
Identifiers
Aliases	MAP1A, MAP1L, MTAP1A, microtubule associated protein 1A
External IDs	OMIM: 600178; MGI: 1306776; HomoloGene: 1778; GeneCards: MAP1A; OMA:MAP1A - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2 E5|2 60.37 cM Start 121,120,081 bp[1] End 121,141,313 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 external globus pallidus Region I of hippocampus proper postcentral gyrus Brodmann area 46 superior vestibular nucleus pons entorhinal cortex orbitofrontal cortex frontal pole Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell subiculum pontine nuclei central gray substance of midbrain medial vestibular nucleus prefrontal cortex dorsal tegmental nucleus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding structural molecule activity actin binding cytoskeletal anchor activity tubulin binding tau protein binding Cellular component cytoplasm microtubule cytoskeleton microtubule associated complex cytosol axon dendrite cell projection neuron projection neuronal cell body axon initial segment dendritic shaft dendritic branch synapse primary dendrite dendritic microtubule axon cytoplasm Biological process microtubule cytoskeleton organization axonogenesis memory associative learning dendrite development regulation of microtubule depolymerization negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of synaptic plasticity voluntary musculoskeletal movement neuron cellular homeostasis anterograde axonal protein transport retrograde axonal protein transport negative regulation of protein localization to microtubule positive regulation of protein localization neuron projection maintenance positive regulation of protein localization to cell surface Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4130 17754 Ensembl n/a ENSMUSG00000027254 UniProt P78559 Q9QYR6 RefSeq (mRNA) NM_002373 NM_001173506 NM_032393 RefSeq (protein) NP_002364 NP_001166977 NP_115769 Location (UCSC) n/a Chr 2: 121.12 – 121.14 Mb PubMed search [2] [3]
Wikidata
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Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.^[4][5][6]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.^[6]

MAP1A has been shown to interact with DISC1.^[7]

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