Contents

MAP3K14

Protein-coding gene in the species Homo sapiens

MAP3K14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DN5, 4G3D, 4IDT, 4IDV
Identifiers
Aliases	MAP3K14, FTDCR1B, HS, HSNIK, NIK, mitogen-activated protein kinase kinase kinase 14
External IDs	OMIM: 604655; MGI: 1858204; HomoloGene: 2940; GeneCards: MAP3K14; OMA:MAP3K14 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,263,119 bp[1] End 45,317,029 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 66.8 cM Start 103,110,588 bp[2] End 103,158,298 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte gastrocnemius muscle muscle layer of sigmoid colon apex of heart gastric mucosa lymph node tibialis anterior muscle spleen right auricle anterior pituitary Top expressed in granulocyte lumbar spinal ganglion gastrula submandibular gland blood mesenteric lymph nodes muscle of thigh thymus spleen lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding NF-kappaB-inducing kinase activity protein binding MAP kinase kinase kinase activity ATP binding kinase activity protein serine/threonine kinase activity Cellular component cytoplasm fibrillar center nucleus cytosol intracellular membrane-bounded organelle Biological process phosphorylation tumor necrosis factor-mediated signaling pathway MAPK cascade protein phosphorylation cellular response to mechanical stimulus immune response positive regulation of I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling NIK/NF-kappaB signaling regulation of mitotic cell cycle signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9020 53859 Ensembl ENSG00000006062 ENSG00000282637 ENSMUSG00000020941 UniProt Q99558 Q9WUL6 RefSeq (mRNA) NM_003954 NM_016896 RefSeq (protein) NP_003945 NP_058592 Location (UCSC) Chr 17: 45.26 – 45.32 Mb Chr 11: 103.11 – 103.16 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.^[5][6]

This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.^[6]

MAP3K14 has been shown to interact with:

• CHUK,^{[7][8][9][10]}
• IKK2,^[7][11] and
• TRAF2.^[5][7]

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.