C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.[5][6]
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.[7]
MAPK8IP1 has been shown to interact with MAP3K10,[8] DUSP16,[9] Mitogen-activated protein kinase 9,[8][10] MAPK8,[10][11] LRP2,[12][13] LRP1,[12] MAP3K12,[8] MAP2K7,[8] MAPK8IP2[8] and MAP3K11.[8]
PDB gallery
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2fpd: Sad structure determination: crystal structure of the intrinsic dimerization sh3 domain of the ib1 scaffold protein
2fpe: Conserved dimerization of the ib1 src-homology 3 domain
2fpf: Crystal structure of the ib1 sh3 dimer at low resolution
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