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(Top) 1 Function 2 Interactions 3 References 4 Further reading

MAPRE2

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MAPRE2

Identifiers

Aliases

MAPRE2, EB1, EB2, RP1, CSCSC2, microtubule associated protein RP/EB family member 2

External IDs

OMIM: 605789; MGI: 106271; HomoloGene: 75027; GeneCards: MAPRE2; OMA:MAPRE2 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q12.1-q12.2	Start	34,976,928 bp^[1]
Band	18q12.1-q12.2	End	35,143,470 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18 A2\|18 12.08 cM	Start	23,885,390 bp^[2]
Band	18 A2\|18 12.08 cM	End	24,026,918 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

spinal ganglia

corpus callosum

inferior ganglion of vagus nerve

C1 segment

parietal lobe

prefrontal cortex

subthalamic nucleus

postcentral gyrus

entorhinal cortex

pons

Top expressed in

Rostral migratory stream

nucleus accumbens

motor neuron

ciliary body

barrel cortex

iris

substantia nigra

retinal pigment epithelium

dorsal striatum

external carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule binding protein binding identical protein binding protein kinase binding microtubule plus-end binding
Cellular component	microtubule cytoskeleton microtubule plus-end microtubule cytoskeleton cytoplasm microtubule organizing center cytoplasmic microtubule focal adhesion spindle midzone
Biological process	cell cycle cell population proliferation signal transduction cell division regulation of microtubule polymerization or depolymerization positive regulation of ARF protein signal transduction protein localization to microtubule positive regulation of GTPase activity spindle assembly positive regulation of keratinocyte migration positive regulation of adherens junction organization protein localization to microtubule plus-end
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10982


212307

Ensembl


ENSG00000166974


ENSMUSG00000024277

UniProt


Q15555


Q8R001

RefSeq (mRNA)


NM_001143826 NM_001143827 NM_001256420 NM_014268


NM_001162941 NM_001162942 NM_153058

RefSeq (protein)


NP_001137298 NP_001137299 NP_001243349 NP_055083


NP_001156413 NP_001156414 NP_694698

Location (UCSC)

Chr 18: 34.98 – 35.14 Mb

Chr 18: 23.89 – 24.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.^[5]^[6]^[7]

Function[edit]

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.^[7]

Interactions[edit]

MAPRE2 has been shown to interact with APC.^[8]^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166974 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024277 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi:10.4049/jimmunol.159.3.1276. PMID 9233623. S2CID 23797920.

^ Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC 138635. PMID 12475954.

^ ^a ^b "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2".

^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.

^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Bibcode:2001CBio...11.1062N. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. S2CID 14122895.

Further reading[edit]

Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell Biol. 149 (4): 761–6. doi:10.1083/jcb.149.4.761. PMC 2174556. PMID 10811817.

Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.

Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE (1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10596–601. Bibcode:1998PNAS...9510596B. doi:10.1073/pnas.95.18.10596. PMC 27940. PMID 9724749.

Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene. 17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID 10030671. S2CID 25818701.

Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z. PMID 10188731. S2CID 33232892.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Nakamura M, Zhou XZ, Lu KP (2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Bibcode:2001CBio...11.1062N. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. S2CID 14122895.

Askham JM, Vaughan KT, Goodson HV, Morrison EE (2003). "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.

Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.

Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.

Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.

Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. doi:10.1186/1471-2121-6-23. PMC 1097723. PMID 15862129.

Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene. 24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID 16007168. S2CID 36511735.

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