Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[5][6]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6] MEOX2 has been implicated in the initiation of tumors in glioma.[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.[8][9]
MEOX2 has been shown to interact with PAX1[10] and PAX3.[10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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