Contents

Melanotransferrin

Protein-coding gene in the species Homo sapiens

MELTF
Identifiers
Aliases	MELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDs	OMIM: 155750; MGI: 1353421; HomoloGene: 4335; GeneCards: MELTF; OMA:MELTF - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 196,980,590 bp[1] End 197,029,835 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B2 Start 31,697,628 bp[2] End 31,717,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parotid gland decidua tendon of biceps brachii renal medulla parietal pleura cartilage tissue endothelial cell amniotic fluid germinal epithelium Top expressed in vestibular sensory epithelium stria vascularis epithelium of small intestine trachea migratory enteric neural crest cell utricle vestibular membrane of cochlear duct intercostal muscle ankle joint condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding protein binding metal ion binding Cellular component cell surface anchored component of plasma membrane anchored component of membrane integral component of plasma membrane extracellular exosome membrane extracellular region extracellular space plasma membrane endoplasmic reticulum lumen Biological process positive regulation of extracellular matrix disassembly iron ion homeostasis negative regulation of substrate adhesion-dependent cell spreading regulation of cell population proliferation positive regulation of plasminogen activation ion transport regulation of cell growth C-terminal protein lipidation post-translational protein modification transport iron ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4241 30060 Ensembl ENSG00000163975 ENSMUSG00000022780 UniProt P08582 Q9R0R1 RefSeq (mRNA) NM_005929 NM_033316 NM_013900 RefSeq (protein) NP_005920 NP_201573 NP_038928 Location (UCSC) Chr 3: 196.98 – 197.03 Mb Chr 16: 31.7 – 31.72 Mb PubMed search [3] [4]
Wikidata
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Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.^[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

References[edit]

Further reading[edit]

External links[edit]

• MFI2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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