MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[5][6]
MNK2 has been shown to interact with MAPK1[7][8] and Eukaryotic translation initiation factor 4 gamma.[7]
MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.[9]
PDB gallery
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2ac3: Structure of human Mnk2 Kinase Domain
2ac5: Structure of human Mnk2 Kinase Domain mutant D228G
2hw7: Crystal Structure of Mnk2-D228G in complex with Staurosporine
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