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| Names | |
|---|---|
| IUPAC name
6-O-Phosphono-D-mannopyranose | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChemSpider |
 YY |
| MeSH | mannose-6-phosphate |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| |
| |
| Properties | |
| C6H13O9P | |
| Molar mass | 260.136 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphatebymannose phosphate isomerase.
M6P is a key targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme N-acetylglucosamine-1-phosphate transferase catalyzes the N-linked glycosylationofasparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi network. There, the M6P moiety is recognized and bound by mannose 6-phosphate receptor (MPR) proteins at pH 6.5–6.7.[1]
The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport.[1] Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate.[2] The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor.[1] Upon release, the enzymes are ferried to their final destination in the lysosomes.[1] The MPRs are packed into vesicles that bud off the late endosome and return to the trans-Golgi network.[1] In this way, the MPRs can be recycled.
