Lewis compiled the biography of one of her ancestors, Edward Hyde, 1st Earl of Clarendon. In 1852 Lewis published her first work which was a group of biographies based on the people known to Edward Hyde, the Earl of Clarendon, and it was titled The Lives of the Friends and Contemporaries of Lord Chancellor Clarendon. The book was intended to illustrate the portraits in Clarendon's gallery at The Grove, Watford.[3]
Lewis's work so impressed the writer Mary Berry that she left her papers to Lewis (via Sir Thomas Frankland Lewis) so that Lewis could in 1865 publish Extracts of the Journals and Correspondence of Miss Berry from the year 1783 to 1852.[4]
Lady Lewis also edited a novel by the Hon. Emily Eden called The Semi-Detached House in 1859, and she wrote two plays, based on fairy tales, for children to perform.
On 6 November 1830, Lister married the novelist Thomas Henry Lister, a son of Thomas Lister of Armitage Park, and his first wife Harriet Anne Seale. They had three children:[1]
Thomas Villiers Lister (1832–1902), married first Fanny Harriet Coryton and secondly Florence Selina Hamilton, daughter of geologist William Hamilton and his second wife Margaret Frances Florence Dillon.
Two years after the death of Sir George, Lady Lewis died from cancer in 1865 at Brasenose College, Oxford when paying a visit to the Principal.[7] She was initially buried on 14 November 1865 in Holywell Cemetery, Oxford,[8] but the parish register of St Mary-the-Virgin Church records that “her remains were subsequently removed by the family”. She was eventually laid to rest beside her second husband (as she had wished) in St Stephen's Church, Old Radnor and her family erected a memorial to her on the wall of that church.