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Martin Edward Kreitman is an American geneticist at the University of Chicago ,[3] [4] [5] McDonald–Kreitman test that is used to infer the amount of adaptive evolution in population genetic studies.
Education
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Kreitman graduated from Stony Brook University with a Bachelor of Science degree Biology in 1975, and from the University of Florida with a Master of Science degree in Zoology , in 1977. He went on to study at Harvard University , graduating with a Ph.D. in Population Genetics , specifically Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster [6] [7]
Research
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The Kreitman lab does research in four main areas:[8] [9] [10] [11]
"Functional evolution of cis-regulatory sequences (Drosophila )"[12]
"Molecular population genetics and evolution (Drosophila and Arabidopsis )"[12]
"Canalization in development and evolution (Drosophila)"[12]
"Evolutionary dynamics of disease resistance and pathogenicity (Arabidopsis)"[12]
Awards and honors
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Recent publications
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Ludwig, M. Z.; Manu; Kittler, R.; White, K. P.; Kreitman, M. (2011). Malik, Harmit S (ed.). "Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness" . PLOS Genetics . 7 11 ): e1002364. doi :10.1371/journal.pgen.1002364 PMC 3213169 PMID 22102826 .
He, B. Z.; Holloway, A. K.; Maerkl, S. J.; Kreitman, M. (2011). Petrov, Dmitri A (ed.). "Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules" . PLOS Genetics . 7 4 ): e1002053. doi :10.1371/journal.pgen.1002053 PMC 3084208 PMID 21572512 .
Lott, S. E.; Ludwig, M. Z.; Kreitman, M. (2011). "Evolution and Inheritance of Early Embryonic Patterning in Drosophila Simulans and D. Sechellia" . Evolution . 65 5 ): 1388–1399. doi :10.1111/j.1558-5646.2010.01206.x . PMC 3083464 PMID 21121913 .
Bakker, E. G.; Traw, M. B.; Toomajian, C.; Kreitman, M.; Bergelson, J. (2008). "Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana" . Genetics . 178 (4 ): 2031–2043. doi :10.1534/genetics.107.083279 . PMC 2323794 PMID 18245336 .
Araki, H.; Innan, H.; Kreitman, M.; Bergelson, J. (2007). "Molecular Evolution of Pathogenicity-Island Genes in Pseudomonas viridiflava" . Genetics . 177 (2 ): 1031–1041. doi :10.1534/genetics.107.077925 . PMC 2034611 PMID 17720907 .
Lott, S. E.; Kreitman, M.; Palsson, A.; Alekseeva, E.; Ludwig, M. Z. (2007). "Canalization of segmentation and its evolution in Drosophila" . Proceedings of the National Academy of Sciences . 104 (26 ): 10926–10931. Bibcode :2007PNAS..10410926L . doi :10.1073/pnas.0701359104 PMC 1891814 PMID 17569783 .
Bakker, E. G. (2006). "A Genome-Wide Survey of R Gene Polymorphisms in Arabidopsis" . The Plant Cell Online . 18 8 ): 1803–1818. doi :10.1105/tpc.106.042614 . PMC 1533970 PMID 16798885 .
Bakker, E. G.; Stahl, E. A.; Toomajian, C.; Nordborg, M.; Kreitman, M.; Bergelson, J. (2006). "Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range". Molecular Ecology . 15 5 ): 1405–1418. Bibcode :2006MolEc..15.1405B . doi :10.1111/j.1365-294X.2006.02884.x . PMID 16626462 . S2CID 2070755 .
Araki, H. (2006). "Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis" . Proceedings of the National Academy of Sciences . 103 (15 ): 5887–5892. Bibcode :2006PNAS..103.5887A . doi :10.1073/pnas.0601431103 PMC 1458668 PMID 16581904 .
Nordborg, M.; Hu, T. T.; Ishino, Y.; Jhaveri, J.; Toomajian, C.; Zheng, H.; Bakker, E.; Calabrese, P.; Gladstone, J.; Goyal, R.; Jakobsson, M.; Kim, S.; Morozov, Y.; Padhukasahasram, B.; Plagnol, V.; Rosenberg, N. A.; Shah, C.; Wall, J. D.; Wang, J.; Zhao, K.; Kalbfleisch, T.; Schulz, V.; Kreitman, M.; Bergelson, J. (2005). "The Pattern of Polymorphism in Arabidopsis thaliana" . PLOS Biology . 3 7 ): e196. doi :10.1371/journal.pbio.0030196 PMC 1135296 PMID 15907155 .
Ludwig, M. Z.; Palsson, A.; Alekseeva, E.; Bergman, C. M.; Nathan, J.; Kreitman, M. (2005). "Functional Evolution of a cis-Regulatory Module" . PLOS Biology . 3 4 ): e93. doi :10.1371/journal.pbio.0030093 PMC 1064851 PMID 15757364 .
Kreitman, M.; Di Rienzo, A. (2004). "Balancing claims for balancing selection". Trends in Genetics . 20 7 ): 300–304. doi :10.1016/j.tig.2004.05.002 . PMID 15219394 .
Goss, E. M.; Kreitman, M.; Bergelson, J. (2004). "Genetic Diversity, Recombination and Cryptic Clades in Pseudomonas viridiflava Infecting Natural Populations of Arabidopsis thaliana" . Genetics . 169 (1 ): 21–35. doi :10.1534/genetics.104.031351 . PMC 1448860 PMID 15489535 .
Mauricio, R.; Stahl, E. A.; Korves, T.; Tian, D.; Kreitman, M.; Bergelson, J. (2003). "Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana" . Genetics . 163 (2 ): 735–746. doi :10.1093/genetics/163.2.735 . PMC 1462445 PMID 12618410 .
Tian, D.; Traw, M. B.; Chen, J. Q.; Kreitman, M.; Bergelson, J. (2003). "Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana". Nature . 423 (6935): 74–77. Bibcode :2003Natur.423...74T . doi :10.1038/nature01588 . PMID 12721627 . S2CID 4394776 .
Toomajian, C.; Ajioka, R. S.; Jorde, L. B.; Kushner, J. P.; Kreitman, M. (2003). "A method for detecting recent selection in the human genome from allele age estimates" . Genetics . 165 (1 ): 287–297. doi :10.1093/genetics/165.1.287 . PMC 1462736 PMID 14504236 .
Tian, D. (2002). "Signature of balancing selection in Arabidopsis" . Proceedings of the National Academy of Sciences . 99 17 ): 11525–11530. Bibcode :2002PNAS...9911525T . doi :10.1073/pnas.172203599 PMC 123289 PMID 12172007 .
Toomajian, C.; Kreitman, M. (2002). "Sequence variation and haplotype structure at the human HFE locus" . Genetics . 161 (4 ): 1609–1623. doi :10.1093/genetics/161.4.1609 . PMC 1462210 PMID 12196404 .
Jakob, K.; Goss, E. M.; Araki, H.; Van, T.; Kreitman, M.; Bergelson, J. (2002). "Pseudomonas viridiflavaandP. Syringae—Natural Pathogens ofArabidopsis thaliana". Molecular Plant-Microbe Interactions . 15 12 ): 1195–1203. doi :10.1094/MPMI.2002.15.12.1195 . PMID 12481991 .
Comeron, J. M.; Kreitman, M. (2002). "Population, evolutionary and genomic consequences of interference selection" . Genetics . 161 (1 ): 389–410. doi :10.1093/genetics/161.1.389 . PMC 1462104 PMID 12019253 .
Nordborg, M.; Borevitz, J. O.; Bergelson, J.; Berry, C. C.; Chory, J.; Hagenblad, J.; Kreitman, M.; Maloof, J. N.; Noyes, T.; Oefner, P. J.; Stahl, E. A.; Weigel, D. (2002). "The extent of linkage disequilibrium in Arabidopsis thaliana". Nature Genetics . 30 2 ): 190–193. doi :10.1038/ng813 . PMID 11780140 . S2CID 29420110 .
Bergman, C. M.; Kreitman, M. (2001). "Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences" . Genome Research . 11 8 ): 1335–1345. doi :10.1101/gr.178701 PMID 11483574 .
Bergelson, J.; Kreitman, M.; Stahl, E. A.; Tian, D. (2001). "Evolutionary Dynamics of Plant R-Genes". Science . 292 (5525): 2281–2285. doi :10.1126/science.1061337 . PMID 11423651 . S2CID 21638017 .
Comeron, J. M.; Kreitman, M. (2000). "The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces" . Genetics . 156 (3 ): 1175–1190. doi :10.1093/genetics/156.3.1175 . PMC 1461334 PMID 11063693 .
Ludwig, M. Z.; Bergman, C.; Patel, N. H.; Kreitman, M. (2000). "Evidence for stabilizing selection in a eukaryotic enhancer element". Nature . 403 (6769): 564–567. Bibcode :2000Natur.403..564L . doi :10.1038/35000615 . PMID 10676967 . S2CID 4425113 .
Bergelson, J.; Stahl, E. A.; Dwyer, G.; Mauricio, R.; Kreitman, M. (1999). "Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis". Nature . 400 (6745): 667–671. Bibcode :1999Natur.400..667S . doi :10.1038/23260 . PMID 10458161 . S2CID 4380447 .
Comeron, J. M.; Kreitman, M.; Aguadé, M. (1999). "Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila" . Genetics . 151 (1 ): 239–249. doi :10.1093/genetics/151.1.239 . PMC 1460462 PMID 9872963 .
Ludwig, M. Z.; Patel, N. H.; Kreitman, M. (1998). "Functional analysis of eve stripe 2 enhancer evolution in Drosophila: Rules governing conservation and change". Development . 125 (5 ): 949–958. doi :10.1242/dev.125.5.949 . PMID 9449677 .
References
[ edit ]
^ "Bio" . pondside.uchicago.edu . Retrieved 2021-01-05 .
^ "Martin Kreitman | Recovery Act Funding | the University of Chicago" .
^ Martin Kreitman's publications indexed by the Scopus bibliographic database. (subscription required)
^ Kreitman, Martin Edward (1983). Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster (PhD thesis). Harvard University. ProQuest 303271509 .
^ "University of Chicago - Molecular Biosciences" . Archived from the original on 2010-06-10. Retrieved 2010-04-25 .
^ Kreitman, M. (1983). "Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster". Nature . 304 (5925): 412–417. Bibcode :1983Natur.304..412K . doi :10.1038/304412a0 . PMID 6410283 . S2CID 4348580 .
^ McDonald, J. H.; Kreitman, Martin (1991). "Adaptive protein evolution at the Adh locus in Drosophila". Nature . 351 (6328): 652–654. Bibcode :1991Natur.351..652M . doi :10.1038/351652a0 . PMID 1904993 . S2CID 205024070 .
^ Hudson, R. R.; Kreitman, M.; Aguadé, M. (1987). "A test of neutral molecular evolution based on nucleotide data" . Genetics . 116 (1 ): 153–159. doi :10.1093/genetics/116.1.153 . PMC 1203113 PMID 3110004 .
^ Kreitman, Martin (2000). "Methods to detect selection In populations with applications to the human" . Annual Review of Genomics and Human Genetics . 1 doi :10.1146/annurev.genom.1.1.539 PMID 11701640 .
^ a b c d "Faculty | Ecology & Evolution | University of Chicago" . Archived from the original on 2014-07-20.
^ "Faculty of 1000 | About" . www.f1000biology.com . Archived from the original on 8 July 2004. Retrieved 20 July 2022 .
^ "IGSB senior fellow Martin Kreitman named fellow of the American Academy of Arts and Sciences « News & Events « Institute for Genomics and Systems Biology" . www.igsb.org . Archived from the original on 11 September 2010. Retrieved 20 July 2022 .
External links
[ edit ] R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Martin_Kreitman&oldid=1198451553 " C a t e g o r i e s : ● A m e r i c a n g e n e t i c i s t s ● U n i v e r s i t y o f C h i c a g o f a c u l t y ● S t o n y B r o o k U n i v e r s i t y a l u m n i ● U n i v e r s i t y o f F l o r i d a C o l l e g e o f A g r i c u l t u r a l a n d L i f e S c i e n c e s a l u m n i ● H a r v a r d U n i v e r s i t y a l u m n i ● F e l l o w s o f t h e A m e r i c a n A c a d e m y o f A r t s a n d S c i e n c e s ● M a c A r t h u r F e l l o w s ● L i v i n g p e o p l e H i d d e n c a t e g o r i e s : ● P a g e s c o n t a i n i n g l i n k s t o s u b s c r i p t i o n - o n l y c o n t e n t ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● A r t i c l e s w i t h h C a r d s ● A r t i c l e s w i t h t o o m a n y e x a m p l e s f r o m J a n u a r y 2 0 2 1 ● A l l a r t i c l e s w i t h t o o m a n y e x a m p l e s ● W i k i p e d i a a r t i c l e s w i t h s t y l e i s s u e s f r o m J a n u a r y 2 0 2 1 ● Y e a r o f b i r t h m i s s i n g ( l i v i n g p e o p l e )
● T h i s p a g e w a s l a s t e d i t e d o n 2 4 J a n u a r y 2 0 2 4 , a t 0 4 : 3 9 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
