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Matrix metalloproteinase inhibitor

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Amatrix metalloproteinase inhibitor (INN stem –mastat^[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.

Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.^[2] Examples include:

Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.^[3]

References[edit]

^ Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science. 295 (5564): 2387–2392. Bibcode:2002Sci...295.2387C. doi:10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. S2CID 19944201.

^ Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International. 2010: 845975. doi:10.1155/2010/845975. PMC 3004377. PMID 21197102.

Class

Substrate

Oxidoreductase (EC 1)	1.1 Aldose reductase HMG-CoA reductase 1.3 5α-Reductase 1.4 Monoamine oxidase 1.5 Dihydrofolate reductase 1.13 Lipoxygenase 1.14 Aromatase COX-2 1.17 Xanthine oxidase Ribonucleotide reductase
Transferase (EC 2)	2.1 COMT Thymidylate synthase 2.4 PARP 2.5 Dihydropteroate synthetase Farnesyltransferase 2.6 GABA transaminase 2.7 Nucleotidyltransferase Integrase Reverse transcriptase Protein kinase Tyrosine kinase Janus kinase
Hydrolase (EC 3)	3.1 Phosphodiesterase Acetylcholinesterase Ribonuclease 3.2 Polygalacturonase Neuraminidase Alpha-glucosidase 3.4 Protease: Exopeptidase DPP-4 ACE Endopeptidase Trypsin Renin Mixed Enkephalinase Matrix metalloproteinase Oxytocinase 3.5 Histone deacetylase Beta-lactamase
Lyase (EC 4)	4.1 Dopa decarboxylase 4.2 Carbonic anhydrase
Miscellaneous	Steroidogenesis inhibitor

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