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Melanie Blokesch (born 1976) is a German microbiologist . Her research focuses on Vibrio cholerae cholera . She is a professor of life sciences at École Polytechnique Fédérale de Lausanne (EPFL), where she heads the Laboratory of Molecular Microbiology.[1]
Career
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Blokesch studied biology and microbiology at Ludwig Maximilian University of Munich where she received her diploma in 2000. She then joined August Böck's laboratory as a doctoral student and in 2004, graduated with her PhD awarded summa cum laude on "[NiFe]-Hydrogenases of Escherichia coli : Functions of Proteins involved in Metal Center Assembly".[2] Stanford University .[3] École Polytechnique Fédérale de Lausanne , where she was promoted as Associate Professor in 2016 and Full Professor in 2021. Since 2009, she has been the director of the Laboratory of Molecular Microbiology.[1] [4] [5] [6]
Research
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Blokesch's research group investigates the pathogenic bacterium Vibrio cholerae pandemics throughout history. She is interested how the natural environment of the bacterium is linked to its potential to evolve into a human pathogen.[7]
Her group studies how V. cholerae horizontal gene transfer (HGT).[8] exoskeleton of arthropods , also under conditions of water currents.[9] [10] [11] [12] [10] [13] Acinetobacter baumannii [7] [14]
In order to better understand the interaction of host and pathogen, they also investigate routes of transmission in endemic cholera hot-spots. They discovered several virulence factors that might be used by V. cholerae Trojan horse -like manner to replicate in aquatic amoebae , and thereby could facilitate transmission.[15] [16]
The research of Blokesch and her group has been featured in international news outlets such as La Razón ,[17] Radio Télévision Suisse ,[18] [19] National Geographic Magazine [20] Deutschlandfunk .[21]
Distinctions
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Blokesch was elected as a member of the European Molecular Biology Organization (EMBO) in 2019[22] European Academy of Microbiology in 2018.[23] German news outlets (Edition F, ZEIT online , Handelsblatt and Gründerszene).[24] eLife ,[25] PLoS Genetics ,[26] Molecular Microbiology ,[27] PLoS Biology .[28] [29] Swiss National Science Foundation .[30]
Selected publications
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Sawers, R. Gary; Blokesch, Melanie; Böck, August (2004). "Anaerobic Formate and Hydrogen Metabolism". EcoSal Plus . 1 1 ). doi :10.1128/ecosalplus.3.5.4 . PMID 26443350 .
Meibom, K. L.; Blokesch, M.; Dolganov, N. A.; Wu, C. Y.; Schoolnik, G. K. (2005). "Chitin Induces Natural Competence in Vibrio cholerae". Science . 310 (5755): 1824–1827. Bibcode :2005Sci...310.1824M . doi :10.1126/science.1120096 . PMID 16357262 . S2CID 31153549 .
Böck, August; King, Paul W.; Blokesch, Melanie; Posewitz, Matthew C. (2006). "Maturation of Hydrogenases". Advances in Microbial Physiology Volume 51 . Advances in Microbial Physiology. pp. 1–225. doi :10.1016/S0065-2911(06 )51001-X . ISBN 9780120277513 PMID 17091562 .
Borgeaud, Sandrine; Metzger, Lisa C.; Scrignari, Tiziana; Blokesch, Melanie (2015). "The type VI secretion system of Vibrio choleraefosters horizontal gene transfer". Science . 347 (6217): 63–67. Bibcode :2015Sci...347...63B . doi :10.1126/science.1260064 . PMID 25554784 . S2CID 20297980 .
Blokesch, Melanie; Schoolnik, Gary K. (2007). "Serogroup Conversion of Vibrio cholerae in Aquatic Reservoirs" . PLOS Pathogens . 3 6 ): e81. doi :10.1371/journal.ppat.0030081 PMC 1891326 PMID 17559304 .
Seitz, Patrick; Blokesch, Melanie (2013). "Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria" . FEMS Microbiology Reviews . 37 3 ): 336–363. doi :10.1111/j.1574-6976.2012.00353.x PMID 22928673 .
Rinaldo, A.; Bertuzzo, E.; Mari, L.; Righetto, L.; Blokesch, M.; Gatto, M.; Casagrandi, R.; Murray, M.; Vesenbeckh, S. M.; Rodriguez-Iturbe, I. (2012). "Reassessment of the 2010-2011 Haiti cholera outbreak and rainfall-driven multiseason projections" . Proceedings of the National Academy of Sciences . 109 (17 ): 6602–6607. Bibcode :2012PNAS..109.6602R . doi :10.1073/pnas.1203333109 PMC 3340092 PMID 22505737 .
References
[ edit ]
^ Blokesch, Melanie; Böck, August (2002-11-23). "Maturation of [NiFe]-hydrogenases in Escherichia coli: The HypC Cycle" . Journal of Molecular Biology . 324 (2 ): 287–296. doi :10.1016/S0022-2836(02 )01070-7 . PMID 12441107 .
^ Meibom, K. L. (2005-12-16). "Chitin Induces Natural Competence in Vibrio cholerae" . Science . 310 (5755): 1824–1827. Bibcode :2005Sci...310.1824M . doi :10.1126/science.1120096 . ISSN 0036-8075 . PMID 16357262 . S2CID 31153549 .
^ "BLOKESCH Lab – Laboratory of Molecular Microbiology" . www.epfl.ch . Retrieved 2020-09-24 .
^ Marvig, Rasmus L; Blokesch, Melanie (2010). "Natural transformation of Vibrio cholerae as a tool - Optimizing the procedure" . BMC Microbiology . 10 1 ): 155. doi :10.1186/1471-2180-10-155 ISSN 1471-2180 . PMC 2890613 PMID 20509862 .
^ "15 new professors appointed at ETH Zurich and EPFL | ETH-Board" . www.ethrat.ch . Retrieved 2021-06-03 .
^ a b "Research" . www.epfl.ch . Retrieved 2020-09-24 .
^ Dubnau, David; Blokesch, Melanie (2019-12-03). "Mechanisms of DNA Uptake by Naturally Competent Bacteria" . Annual Review of Genetics . 53 1 ): 217–237. doi :10.1146/annurev-genet-112618-043641 . ISSN 0066-4197 . PMID 31433955 . S2CID 201278448 .
^ Seitz, Patrick; Blokesch, Melanie (2013-10-29). "DNA-uptake machinery of naturally competent Vibrio cholerae" . Proceedings of the National Academy of Sciences . 110 (44 ): 17987–17992. Bibcode :2013PNAS..11017987S . doi :10.1073/pnas.1315647110 ISSN 0027-8424 . PMC 3816411 PMID 24127573 .
^ a b Adams, David. W.; Stutzmann, Sandrine; Stoudmann, Candice; Blokesch, Melanie (2019-06-10). "DNA-uptake pili of Vibrio cholerae are required for chitin colonization and capable of kin recognition via sequence-specific self-interaction" . Nature Microbiology . 4 9 ): 1545–1557. doi :10.1038/s41564-019-0479-5 . ISSN 2058-5276 . PMC 6708440 PMID 31182799 .
^ Metzger, Lisa C.; Stutzmann, Sandrine; Scrignari, Tiziana; Van der Henst, Charles; Matthey, Noémie; Blokesch, Melanie (2016-04-21). "Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY" . Cell Reports . 15 5 ): 951–958. doi :10.1016/j.celrep.2016.03.092 . PMC 4858559 PMID 27117415 .
^ Borgeaud, Sandrine; Metzger, Lisa C.; Scrignari, Tiziana; Blokesch, Melanie (2015-01-02). "The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer" . Science . 347 (6217): 63–67. Bibcode :2015Sci...347...63B . doi :10.1126/science.1260064 . ISSN 0036-8075 . PMID 25554784 . S2CID 20297980 .
^ Matthey, Noémie; Stutzmann, Sandrine; Stoudmann, Candice; Guex, Nicolas; Iseli, Christian; Blokesch, Melanie (2019-09-03). Mignot, Tâm; Weigel, Detlef (eds.). "Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae" . eLife . 8 doi :10.7554/eLife.48212 ISSN 2050-084X . PMC 6783263 PMID 31478834 .
^ Blokesch, Melanie (2017-04-27). "In and out—contribution of natural transformation to the shuffling of large genomic regions" . Current Opinion in Microbiology . 38 doi :10.1016/j.mib.2017.04.001 PMID 28458094 .
^ Van der Henst, Charles; Vanhove, Audrey Sophie; Drebes Dörr, Natália Carolina; Stutzmann, Sandrine; Stoudmann, Candice; Clerc, Stéphanie; Scrignari, Tiziana; Maclachlan, Catherine; Knott, Graham; Blokesch, Melanie (2018-08-27). "Molecular insights into Vibrio cholerae's intra-amoebal host-pathogen interactions" . Nature Communications . 9 1 ): 3460. Bibcode :2018NatCo...9.3460V . doi :10.1038/s41467-018-05976-x . ISSN 2041-1723 . PMC 6110790 PMID 30150745 .
^ Van der Henst, Charles; Scrignari, Tiziana; Maclachlan, Catherine; Blokesch, Melanie (2015-09-22). "An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii" . The ISME Journal . 10 4 ): 897–910. doi :10.1038/ismej.2015.165 . ISSN 1751-7362 . PMC 4705440 PMID 26394005 . S2CID 16465742 .
^ "El cólera "roba" ADN para hacer más daño" . La Razón (in Spanish). 2015-01-02. Retrieved 2020-09-24 .
^ Femmes de science : Mélanie Blokesch - Play RTS , retrieved 2020-09-24
^ "Cholera bacterium kills other bacteria to steal their DNA" . The Times of India . January 3, 2015. Retrieved 2020-09-24 .
^ "Cholera Bacteria Kill Each Other With Spears To Steal DNA" . Science . 2015-01-01. Archived from the original on October 9, 2020. Retrieved 2020-10-07 .
^ "Mikrobiologie - Cholera tötet fremde Zellen mit einem Speer" . Deutschlandfunk (in German). Retrieved 2020-10-07 .
^ "EMBO elects 56 new Members" . EMBO . 11 June 2019. Retrieved 2020-09-24 .
^ "FEMS Expert: Prof Melanie Blokesch" . FEMS . Retrieved 2020-09-24 .
^ "Die 25 Frauen, deren Erfindungen unser Leben verändern" . EDITION F (in German). 2017-06-12. Retrieved 2020-09-24 .
^ "Editors for Microbiology and Infectious Disease" . eLife . Retrieved 2020-09-24 .
^ "PLOS Genetics: A Peer-Reviewed Open-Access Journal" . journals.plos.org . Retrieved 2020-09-24 .
^ "Molecular Microbiology" . Wiley Online Library . Retrieved 2020-09-24 .
^ "PLOS Biology: A Peer-Reviewed Open-Access Journal" . journals.plos.org . Retrieved 2020-09-24 .
^ "SNSF Research Council: nine new members elected - SNF" . www.snf.ch . Retrieved 2020-10-07 .
^ "Members of the Research Council - SNF" . www.snf.ch . Retrieved 2020-10-07 .
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