Melero-Moose developed a style of abstract, mixed-media paintings that reference the landscape and culture of her Northern Paiute people. She painted with acrylic washes with layers rice paper and natural objects, such as willow, tule, cattails, and pine nuts.[5] Great Basin landscape, petroglyphs, and basketry inspired her work.[6]
She specializes in visual mixed-media art and has had her work displayed through the Nevada Arts Council.[7]
To address the invisibility of Indigenous peoples of the Great Basin in the Native American art world, Melero-Moose co-founded the Great Basin Native Artists (GBNA) collective in 2014.[1] She has curated numerous group exhibitions of Great Basin artists, including Great Basin Native Artists (2016) at the Carson City Community Center.[3] The Great Basin Native Arts has partnered with Stewart Indian School Cultural Center and Museum to maintain a changing art gallery featuring regional Indigenous artists.[1]
"Indian people, even though so much of the population was wiped out, we never stopped creating," said Melero-Moose.[1]
Beginning in 2018, the Nevada Museum of Art gave Melero-Moose a fellowship to research and create a directory and archive of Great Basin Native artists.[9]
Besides winning several awards at Santa Fe Indian Market, Melero-Moose was selected by SWAIA as its Santa Fe Indian Market Discovery Fellow in 2016.[8]
^ abcd"Melissa Melero-Moose". Native American Artists Resource Collection Online. Heard Museum Billie Jane Baguley Library and Archives. Retrieved 23 November 2019.