When the Midwest Collegiate Conference was originally formed in 1988, it consisted of six Roman Catholic colleges and universities situated across the MidwesternUnited States. Dubbed the Midwest Catholic Conference, member schools originally competed in only men's and women's basketball, women's volleyball, and men's soccer.
St. Ambrose University's basketball teams joined the conference for the 1990 season, and the school's other sports joined the MCC in 1991. Iowa Wesleyan College joined the conference for the 1995–96 season. The following year, Clarke University left the MCC to participate in NCAA Division III athletics. William Penn University became a member of the Conference in 2001. Marycrest International University ceased operations after the 2001–02 season. Waldorf College joined the conference for the 2003–04 season, completing the nine-school lineup. Clarke University returned to the conference in 2007, and the MCC officially took the name of the Midwest Collegiate Conference.
1988 - The Midwest Collegiate Conference (MCC) was founded as the Midwest Catholic Conference (MCC). Charter members included Clarke College (now Clarke University), Edgewood College, Marycrest University (later Marycrest International University), Mount Mercy College (now Mount Mercy University), Mount St. Clare College (later Ashford University) and Viterbo College (now Viterbo University) beginning the 1988-89 academic year.
1989 - Grand View College (now Grand View University) joined the Midwest Catholic in the 1989-90 academic year.
1989 - The MCC has been renamed as the Midwest Classic Conference (MCC) in the 1989-90 academic year.
1990 - St. Ambrose College (now St. Ambrose University) joined the Midwest Classic (with the rest of their other sports joining the following season) in the 1990-91 academic year.
1995 - Iowa Wesleyan College (later Iowa Wesleyan University) joined the Midwest Classic in the 1995-96 academic year.
1996 - Clarke left the Midwest Classic and the NAIA to join the NCAA Division III ranks and the Northern Illinois-Iowa Conference (NIIC) after the 1995-96 academic year.
2012 - Three institutions left the Midwest Collegiate to join their respective new home primary conferences: Ashford and Iowa Wesleyan as NAIA Independents (Iowa Wesleyan would later apply to join the NCAA Division III ranks and the St. Louis Intercollegiate Athletic Conference [SLIAC] beginning the 2013-14 academic year), and Waldorf to join the Midlands Collegiate Athletic Conference (MCAC), all effective after the 2011-12 academic year.
2015 - The Midwest Collegiate ceased operations as an athletic conference after the 2014-15 academic year; as many schools left to join their respective new home primary conferences beginning the 2015-16 academic year: Grand View and William Penn to the Heart of America Athletic Conference (HAAC), Clarke and Mount Mercy as NAIA Independents (although both would later follow Grand View and William Penn to join the HAAC beginning the 2016-17 academic year), St. Ambrose to the Chicagoland Collegiate Athletic Conference (CCAC), and Viterbo to the North Star Athletic Association (NSAA).