Smet was the founder (1973), and first president (until 1982) of the Christian People's Party political women's organisation, Vrouw en Maatschappij (Woman and Society).[1]
She was elected to the Belgian Chamber of People's Representatives in 1978.[2] In 1985, she became State Secretary of Environmental Affairs, and negotiated an Equal Opportunities portfolio. While Smet's competencies cover all aspects of social emancipation, she focused on violence against women, women's economic position and their participation in decision-making. When Miet Smet became Minister of Labour and Employment in 1991, she kept the Equal Opportunities portfolio.[3]
When she was offered first place in the CD&V list for the European elections in 1999 instead of Wilfried Martens, Martens, at the instigation of then-wife Ilse Schouteden, refused to run at all.[4][5]
She became a Minister of State in 2002, and has been a member of the Flemish Parliament since 2004, and a Belgian senator since 2007.[7]
In 2009, Smet was elected president of the Association of European Parliamentarians with Africa (AWEPA),[8] taking over from former president Dr. Jan Nico Scholten.
On 27 September 2008, Miet married fellow CD&V politician and former Belgian Prime MinisterWilfried Martens.[9] After the death of Martens' first wife, Lieve Verschroeven, the marriage was confirmed in the Catholic Church on 27 April 2013.[10]