Alie-Cox was a four-year standout playing power forwardatVirginia Commonwealth University's Men's basketball team. He quickly became a fan favorite for his defensive presence and shot blocking ability fans dubbed him the “Mo Says No” chant.[1] He started 103 games and totaled 1,092 points, 663 rebounds, 87 steals, 112 assists and 255 blocks in 3,322 minutes. He averaged over 25 minutes a game in his final three years.[2] He also led VCU to its first ever Atlantic 10 Conference championship, earning all tournament team honors. He is the school's all-time leader in field goal percentage.
On April 21, 2017, Alie-Cox signed with the Indianapolis Colts, having not played organized football since his freshman year of high school.[5] He was waived/injured by the Colts on August 5, 2017, after suffering a lower leg injury and was placed on injured reserve.[6] He was released with an injury settlement on August 11, 2017. He was re-signed to the Colts' practice squad on October 7, 2017.[7] He signed a reserve/future contract with the Colts on January 1, 2018.[8]
On September 1, 2018, Alie-Cox was waived by the Colts and was signed to the practice squad the next day.[9][10] He was promoted to the active roster on September 28, 2018.[11] In Week 4, against the Houston Texans, he made his NFL debut and recorded a 17-yard reception.[12] He was waived again on October 3, 2018, and re-signed back to the practice squad.[13][14] He was promoted back to the active roster on October 12, 2018.[15] He recorded his first career touchdown catch, a highlight reel one-handed grab, on a 26-yard reception from Andrew Luck in a 42–28 victory over the Oakland Raiders on October 28, 2018. On December 30, 2019, Alie-Cox was signed to a one-year extension through 2020.
Alie-Cox was placed on the active/physically unable to perform list at the start of training camp on July 28, 2020.[16] He was activated on August 21, 2020.[17] On September 20, 2020, Alie-Cox had five receptions for 111 receiving yards helping the Colts win 28–11 over the Minnesota Vikings.[18]
The Colts placed a second-round restricted free agent tender on March 17, 2021.[19] He signed the one-year contract on May 3.[20]
On March 15, 2022, Alie-Cox signed a three-year, $18 million contract extension with the Colts.[21]