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Contents

   



(Top)
  


1 Clinical relevance  




2 References  




3 External links  













Mucin 5AC






●فارسی
 ●മലയാളം
 ●Татарча / tatarça
 ●Українська
  
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From Wikipedia, the free encyclopedia
  

MUC5AC

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes

5AJN, 5AJP, 5AJO

Identifiers

Aliases

MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming

External IDs

OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs

Gene location (Human)

Chromosome 11 (human)

Chr.

Chromosome 11 (human)[1]

Chromosome 11 (human)

Genomic location for MUC5AC

Genomic location for MUC5AC

Band

11p15.5

Start

1,157,953 bp[1]

End

1,201,138 bp[1]

Gene location (Mouse)

Chromosome 7 (mouse)

Chr.

Chromosome 7 (mouse)[2]

Chromosome 7 (mouse)

Genomic location for MUC5AC

Genomic location for MUC5AC

Band

7 F5|7 87.23 cM

Start

141,342,709 bp[2]

End

141,372,968 bp[2]

Bgee

Mouse (ortholog)

  • olfactory zone of nasal mucosa

  • gastric mucosa

  • body of stomach

  • fundus

  • gallbladder

  • canal of the cervix

  • islet of Langerhans

  • appendix

  • urinary bladder

  • muscle tissue
    • pyloric antrum

  • epithelium of stomach

  • mucous cell of stomach

  • conjunctival fornix

  • duodenum

  • olfactory epithelium

  • quadriceps femoris muscle

  • esophagus

  • cornea

  • pancreas

    • More reference expression data

    BioGPS

    n/a

    Molecular function

    Cellular component

  • Golgi lumen
  • extracellular region
  • extracellular exosome
  • extracellular space
  • plasma membrane
  • mucus layer

    • Biological process

  • O-glycan processing
  • stimulatory C-type lectin receptor signaling pathway

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    4586

    17833

    Ensembl

    ENSG00000215182
    ENSG00000283158

    ENSMUSG00000037974

    UniProt

    P98088

    n/a

    RefSeq (mRNA)

    NM_017511
    NM_001304359

    NM_010844

    RefSeq (protein)

    NP_001291288

    n/a

    Location (UCSC)

    Chr 11: 1.16 – 1.2 Mb

    Chr 7: 141.34 – 141.37 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Mucin-5AC (MUC-5AC) is a protein that in humans is encoded by the MUC5AC gene.[5][6][7]

    MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract it protects against infection by binding to inhaled pathogens that are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,[8] and has also been associated with greater protection against influenza infection.[9]

    Clinical relevance[edit]

    This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[10]

    References[edit]

    1. ^ a b c ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.
  • ^ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
  • ^ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
  • ^ Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.
  • ^ Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. ISSN 1091-6490. PMC 3478656. PMID 23012413.
  • ^ Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

    • External links[edit]

    Mucoproteins

    Mucin

  • CD164
  • MUC1
  • MUC2
  • MUC3A
  • MUC3B
  • MUC4
  • MUC5AC
  • MUC5B
  • MUC6
  • MUC7
  • MUC8
  • MUC12
  • MUC13
  • MUC15
  • MUC16
  • MUC17
  • MUC19
  • MUC20

    • Other

  • Intrinsic factor
  • Orosomucoid
  • Peptidoglycan
  • Phytohaemagglutinin
  • Ovomucin

    • Proteoglycans

    CS/DS

  • Biglycan
  • Versican

    • HS/CS

  • Perlecan

    • CS

  • Neurocan
  • Brevican
  • CD44
  • CSPG4
  • CSPG5
  • Platelet factor 4
  • Structural maintenance of chromosomes 3

    • KS

  • Lumican
  • Keratocan

    • HS

    Other

  • ADAM
  • Alpha 1-antichymotrypsin
  • Apolipoprotein H
  • CD70
  • Asialoglycoprotein
  • Avidin
  • B-cell activating factor
  • 4-1BB ligand
  • Cholesterylester transfer protein
  • Clusterin
  • Colony-stimulating factor
  • Hemopexin
  • Lactoferrin
  • Membrane glycoproteins
  • Myelin protein zero
  • Osteonectin
  • Protein C
  • Protein S
  • Serum amyloid P component
  • Sialoglycoprotein
  • Thrombopoietin
  • Thyroglobulin
  • Thyroxine-binding proteins
  • Transcortin
  • Tumor necrosis factor alpha
  • Uteroglobin
  • Vitronectin


    • Stub icon

    This protein-related article is a stub. You can help Wikipedia by expanding it.

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Mucin_5AC&oldid=1191283089"
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    ●This page was last edited on 22 December 2023, at 16:10 (UTC).
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