| neighbor of BRCA1 gene 2 | |
|---|---|
| Identifiers | |
| Symbol | NBR2 |
| NCBI gene | 10230 |
| HGNC | 20691 |
| RefSeq | NM_005821 |
| Other data | |
| Locus | Chr. 17 q21 |
NBR2 is a gene best known for its location near the breast cancer associated gene BRCA1.[1] Like BRCA1, NBR2 has been a subject of research,[2] but links to breast cancer are currently inconclusive.
NBR2 recently was identified as a glucose starvation-induced long non-coding RNA. NBR2 interacts with AMP-activated protein kinase (AMPK), a critical energy sensor in most eukaryotic cells, and promotes AMPK function to mediate energy stress response. Knockdown of NBR2 attenuates energy stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/autophagy response, and increased tumour development in vivo.[3][4] It is now appreciated that NBR2, a former junk gene, plays critical roles in tumor suppression.[5]
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