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Contents

   



(Top)
  


1 See also  




2 References  













NBUMP






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From Wikipedia, the free encyclopedia
  

NBUMP
Clinical data
ATC code
  • none
Identifiers

  • N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]adamantane-1-carboxamide

CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H39N3O2
Molar mass425.617 g·mol−1
3D model (JSmol)

  • COc1ccccc1N2CCN(CC2)CCCCNC(=O)C34CC5CC(C3)CC(C5)C4

  • InChI=1S/C26H39N3O2/c1-31-24-7-3-2-6-23(24)29-12-10-28(11-13-29)9-5-4-8-27-25(30)26-17-20-14-21(18-26)16-22(15-20)19-26/h2-3,6-7,20-22H,4-5,8-19H2,1H3,(H,27,30)

  • Key:PRZPXKIXNNNNCD-UHFFFAOYSA-N

  (verify)

NBUMP is a highly selective 5-HT1A receptor partial agonist (Ki = 0.1 nM; IA = 40%) with an arylpiperazine structure.[1] It is one of the highest affinity ligands for the 5-HT1A receptor known.[1] It displays 460- and 260-fold selectivity for 5-HT1A over the α1-adrenergic and D2 receptors, respectively.[1]

See also[edit]

References[edit]

  1. ^ a b c Glennon RA (2006). "Strategies for the development of selective serotonergic agents". In Roth BL (ed.). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors). Totowa, NJ: Humana Press. p. 113. ISBN 1-58829-568-0.

Retrieved from "https://en.wikipedia.org/w/index.php?title=NBUMP&oldid=1105896151"
Categories: 
●Drugs not assigned an ATC code
 ●Phenylpiperazines
 ●5-HT1A agonists
 ●Serotonin receptor agonists
 ●Adamantanes
 ●Carboxamides
 ●Phenol ethers
 Hidden categories: 
●Articles with short description
 ●Short description matches Wikidata
 ●Articles without EBI source
 ●Chemical pages without DrugBank identifier
 ●Articles without KEGG source
 ●Drugs with no legal status
  


●This page was last edited on 22 August 2022, at 08:10 (UTC).
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