Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[5][6][7]
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[7]
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PDB gallery
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1snt: Structure of the human cytosolic sialidase Neu2
1so7: Maltose-induced structure of the human cytolsolic sialidase Neu2
1vcu: Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA
2f0z: Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor
2f10: Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor
2f11: Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor
2f12: Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor
2f13: Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor
2f24: Crystal Structure of the Human Sialidase Neu2 E111Q Mutant
2f25: Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor
2f26: Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant
2f27: Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor
2f28: Crystal Structure of the Human Sialidase Neu2 Q116E Mutant
2f29: Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor
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| 3.2.1: Glycoside hydrolases |
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| 3.2.2: Hydrolysing N-Glycosyl compounds |
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