Contents

Neurocan

Protein-coding gene in the species Homo sapiens

NCAN
Identifiers
Aliases	NCAN, CSPG3, neurocan
External IDs	OMIM: 600826; MGI: 104694; HomoloGene: 3229; GeneCards: NCAN; OMA:NCAN - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 19,211,958 bp[1] End 19,252,233 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.15 cM Start 70,545,735 bp[2] End 70,573,523 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence Region I of hippocampus proper postcentral gyrus superior frontal gyrus middle frontal gyrus entorhinal cortex Brodmann area 46 frontal pole Brodmann area 10 Top expressed in ganglionic eminence ventricular zone olfactory bulb Rostral migratory stream olfactory tubercle prefrontal cortex barrel cortex nucleus accumbens superior frontal gyrus dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding hyaluronic acid binding carbohydrate binding extracellular matrix structural constituent Cellular component Golgi lumen extracellular region lysosomal lumen extracellular matrix Biological process chondroitin sulfate catabolic process skeletal system development central nervous system development chondroitin sulfate biosynthetic process extracellular matrix organization dermatan sulfate biosynthetic process cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1463 13004 Ensembl ENSG00000130287 ENSMUSG00000002341 UniProt O14594 P55066 RefSeq (mRNA) NM_004386 NM_007789 RefSeq (protein) NP_004377 NP_031815 Location (UCSC) Chr 19: 19.21 – 19.25 Mb Chr 8: 70.55 – 70.57 Mb PubMed search [3] [4]
Wikidata
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Neurocan core protein is a protein that in humans is encoded by the NCAN gene.^[5][6]

Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration.^[6]

Neurocan is a significant component of the extracellular matrix, and its levels are modulated by a variety of factors, but mice in which the NCAN gene has been knocked out show no easily observable defects in brain development or behavior.^[7] However, a genome-wide association study published in 2011 identified Neurocan as a susceptibility factor for bipolar disorder.^[8] A more comprehensive study published in 2012 confirmed that association.^[9] The 2012 study examined correlations between NCAN alleles and various symptoms of bipolar disorder, and also examined the behavior of NCAN knockout mice. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

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