OTUD5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | OTUD5, DUBA, OTU deubiquitinase 5, MCAND | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300713; MGI: 1859615; HomoloGene: 136483; GeneCards: OTUD5; OMA:OTUD5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. [5]
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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