Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[5][6]
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[6]
PBX2 has been shown to interact with HOXA9.[7]
PDB gallery
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1b72: PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX
1b8i: STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX
1du6: SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN
1lfu: NMR solution structure of the extended PBX homeodomain bound to DNA
1puf: Crystal structure of HoxA9 and Pbx1 homeodomains bound to DNA
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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