Contents

PCDHGB7

Protein-coding gene in the species Homo sapiens

PCDHGB7
Identifiers
Aliases	PCDHGB7, ME6, PCDH-GAMMA-B7, protocadherin gamma subfamily B, 7
External IDs	OMIM: 606304; MGI: 1935199; HomoloGene: 75102; GeneCards: PCDHGB7; OMA:PCDHGB7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,417,645 bp[1] End 141,512,975 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 37,884,653 bp[2] End 37,974,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence Achilles tendon ventricular zone right lung right coronary artery gastric mucosa smooth muscle tissue sural nerve Descending thoracic aorta Top expressed in ganglionic eminence striatum of neuraxis cerebellum cerebellar cortex olfactory bulb neural tube mesencephalon genital tubercle hypothalamus tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56099 93704 Ensembl ENSG00000254122 ENSMUSG00000104063 UniProt Q9Y5F8 Q91XX3 RefSeq (mRNA) NM_032101 NM_018927 NM_033579 RefSeq (protein) NP_061750 NP_115272 NP_291057 Location (UCSC) Chr 5: 141.42 – 141.51 Mb Chr 18: 37.88 – 37.97 Mb PubMed search [3] [4]
Wikidata
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Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.^[5][6]

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.^[6]