cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][5]
PDE4D has been shown to interact with myomegalin[6] and GNB2L1.[7][8]
Mutations in this gene have been associated to cases of acrodysostosis.[9]
This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.[10]
Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker. [11] [12] [13]
PDB gallery
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1mkd: crystal structure of PDE4D catalytic domain and zardaverine complex
1oyn: Crystal structure of PDE4D2 in complex with (R,S)-rolipram
1ptw: The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis
1q9m: Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
1tb7: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP
1tbb: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram
1xom: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast
1xon: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast
1xoq: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast
1xor: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine
1y2b: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2c: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2d: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2e: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-amino-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2k: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
1zkn: Structure of PDE4D2-IBMX
2fm0: Crystal structure of PDE4D in complex with L-869298
2fm5: Crystal structure of PDE4D2 in complex with inhibitor L-869299
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