Protein pelota homolog is a protein that in humans is encoded by the PELO gene.[5][6]
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.[6] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.[7] It is a paralog of the release factor eRF1.
The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.[8] Human, yeast (Dom34), plant, and worm homologs are reported in 1995,[9] followed by one found in archaea.[10]
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PDB gallery
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1x52: Solution structures of the C-terminal domain of the human Pelota homolog (CGI-17)
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