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(Top) 1 Interactions 2 References 3 Further reading 4 External links

PEX26

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PEX26

Identifiers

Aliases

PEX26, PBD7A, PBD7B, PEX26M1T, Pex26pM1T, peroxisomal biogenesis factor 26

External IDs

OMIM: 608666; MGI: 1921293; HomoloGene: 9922; GeneCards: PEX26; OMA:PEX26 - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q11.21	Start	18,077,923 bp^[1]
Band	22q11.21	End	18,105,396 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 F1	Start	121,160,626 bp^[2]
Band	6\|6 F1	End	121,175,796 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

tendon of biceps brachii

islet of Langerhans

prefrontal cortex

rectum

ganglionic eminence

stromal cell of endometrium

anterior cingulate cortex

duodenum

ventricular zone

Top expressed in

secondary oocyte

Paneth cell

primary oocyte

lacrimal gland

left lung lobe

medullary collecting duct

hair follicle

left lobe of liver

otic vesicle

transitional epithelium of urinary bladder

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ATPase binding protein C-terminus binding protein binding protein-containing complex binding
Cellular component	integral component of membrane peroxisome membrane integral component of peroxisomal membrane peroxisomal membrane
Biological process	protein transport protein import into peroxisome matrix protein import into peroxisome membrane protein targeting to peroxisome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55670


74043

Ensembl


ENSG00000215193


ENSMUSG00000067825

UniProt


Q7Z412


Q8BGI5

RefSeq (mRNA)


NM_017929 NM_001127649 NM_001199319


NM_028730 NM_001304773 NM_001304774

RefSeq (protein)


NP_001121121 NP_001186248 NP_060399 NP_001121121.1 NP_060399.1


NP_001291702 NP_001291703 NP_083006

Location (UCSC)

Chr 22: 18.08 – 18.11 Mb

Chr 6: 121.16 – 121.18 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.^[5]^[6]^[7]

Interactions

[edit]

PEX26 has been shown to interact with PEX1,^[5] PEX6^[5] and SUFU.^[8]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000215193 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067825 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b ^c Matsumoto N, Tamura S, Fujiki Y (May 2003). "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes". Nature Cell Biology. 5 (5): 454–60. doi:10.1038/ncb982. PMID 12717447. S2CID 2426040.

^ Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y (Aug 2003). "Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation". American Journal of Human Genetics. 73 (2): 233–46. doi:10.1086/377004. PMC 1180364. PMID 12851857.

^ "Entrez Gene: PEX26 peroxisome biogenesis factor 26".

^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.

Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (Mar 2005). "Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis". Journal of Molecular Biology. 346 (5): 1275–86. doi:10.1016/j.jmb.2005.01.013. PMID 15713480.

Weller S, Cajigas I, Morrell J, Obie C, Steel G, Gould SJ, Valle D (Jun 2005). "Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis". American Journal of Human Genetics. 76 (6): 987–1007. doi:10.1086/430637. PMC 1196456. PMID 15858711.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y (Jan 2006). "Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex". The Journal of Biological Chemistry. 281 (3): 1317–23. doi:10.1074/jbc.M510044200. PMID 16257970.

Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H (Jun 2006). "Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites". Journal of Cell Science. 119 (Pt 12): 2508–17. doi:10.1242/jcs.02979. PMID 16763195. S2CID 20304149.

Tamura S, Yasutake S, Matsumoto N, Fujiki Y (Sep 2006). "Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p". The Journal of Biological Chemistry. 281 (38): 27693–704. doi:10.1074/jbc.M605159200. PMID 16854980.

External links

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