PFBS has a half-life of a little over one month in humans, much shorter than PFOS with 5.4 years.[5] PFBS is persistent in the environment. Studies have not yet been specifically conducted to determine safety in humans.
"The combined intrinsic properties justifying the inclusion as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following: very high persistence, high mobility in water and soil, high potential for long-range transport, and difficulty of remediation and water purification as well as moderate bioaccumulation in humans. The observed probable serious effects for human health and the environment are thyroid hormonal disturbances and reproductive toxicity seen in rodents, and effects on liver, kidney and haematological system in rats, hormonal disturbances and effects on reproduction in marine medaka fish and effects on expression of hormone receptors in tadpoles. Together, these elements lead to a very high potential for irreversible effects."[6]
British Columbia currently provides soil standards for perfluorobutane sulfonate (PFBS).[7] In November 2017, the BC Ministry of Environment and Climate Change Strategy released soil and water standards for three PFAS including perfluorobutane sulfonate to the British Columbia Contaminated Sites Regulation.[8]
On 2020-01-16, PFBS and its salts were added to the REACH Regulation Candidate List of Substances of Very High Concern (SVHCs) on the grounds of "Equivalent level of concern having probable serious effects to human health (Article 57(f) – human health)" and "Equivalent level of concern having probable serious effects to the environment (Article 57(f) – environment)".[6]
In 2023, the EPA proposed a drinking water standard that included PFBS.[9] A few states have proposed or implemented regulations on PFBS in drinking watering either as contamination standards, guidance or health advisories.[10]
In 2020, Michigan adopted drinking water standards for 5 previously unregulated PFAS compounds, including PFBS which has a maximum contaminant level (MCL) of 420 parts per trillion (ppt).[11][12]
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