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(Top) 1 References 2 Further reading

PMP2

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PMP2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2WUT, 3NR3, 4A1H, 4A1Y, 4A8Z, 4BVM, 4D6A, 4D6B

Identifiers

Aliases

PMP2, FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein, CMT1G

External IDs

OMIM: 170715; MGI: 102667; HomoloGene: 20589; GeneCards: PMP2; OMA:PMP2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.13	Start	81,440,326 bp^[1]
Band	8q21.13	End	81,447,439 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 A1\|3 2.54 cM	Start	10,244,911 bp^[2]
Band	3 A1\|3 2.54 cM	End	10,248,989 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

olfactory bulb

superior vestibular nucleus

trigeminal ganglion

inferior ganglion of vagus nerve

ventral tegmental area

subthalamic nucleus

external globus pallidus

pars reticulata

Pars compacta

internal globus pallidus

Top expressed in

blastocyst

morula

spermatocyte

neural layer of retina

skeletal muscle tissue

quadriceps femoris muscle

zone of skin

testicle

esophagus

white adipose tissue

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	fatty acid binding cholesterol binding protein binding lipid binding transporter activity
Cellular component	cytoplasm myelin sheath extracellular exosome
Biological process	membrane organization transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5375


18857

Ensembl


ENSG00000147588


ENSMUSG00000052468

UniProt


P02689


P24526

RefSeq (mRNA)


NM_002677 NM_001348381


NM_001030305

RefSeq (protein)


NP_002668 NP_001335310


NP_001025476

Location (UCSC)

Chr 8: 81.44 – 81.45 Mb

Chr 3: 10.24 – 10.25 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene.^[5]^[6]^[7] Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins (FABPs).

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147588 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052468 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K (Jan 1992). "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin". Biochem Biophys Res Commun. 181 (1): 204–7. doi:10.1016/S0006-291X(05)81402-0. PMID 1720307.

^ Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N (Feb 1994). "Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)". Genomics. 18 (2): 244–8. doi:10.1006/geno.1993.1462. PMID 8288226.

^ "Entrez Gene: PMP2 peripheral myelin protein 2".

Further reading[edit]

Narayanan V, Barbosa E, Reed R, Tennekoon G (1988). "Characterization of a cloned cDNA encoding rabbit myelin P2 protein". J. Biol. Chem. 263 (17): 8332–7. doi:10.1016/S0021-9258(18)68481-9. PMID 2453513.

Jones TA, Bergfors T, Sedzik J, Unge T (1988). "The three-dimensional structure of P2 myelin protein". EMBO J. 7 (6): 1597–604. doi:10.1002/j.1460-2075.1988.tb02985.x. PMC 457142. PMID 2458918.

Ishaque A, Hofmann T, Eylar EH (1982). "The complete amino acid sequence of the rabbit P2 protein". J. Biol. Chem. 257 (2): 592–5. doi:10.1016/S0021-9258(19)68231-1. PMID 6172423.

Suzuki M, Kitamura K, Sakamoto Y, Uyemura K (1983). "The complete amino acid sequence of human P2 protein". J. Neurochem. 39 (6): 1759–62. doi:10.1111/j.1471-4159.1982.tb08017.x. PMID 6183401. S2CID 43779591.

Trapp BD, Dubois-Dalcq M, Quarles RH (1984). "Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells". J. Neurochem. 43 (4): 944–8. doi:10.1111/j.1471-4159.1984.tb12828.x. PMID 6206203. S2CID 37059056.

Narayanan V, Ripepi B, Jabs EW, et al. (1994). "Partial structure and mapping of the human myelin P2 protein gene" (PDF). J. Neurochem. 63 (6): 2010–3. doi:10.1046/j.1471-4159.1994.63062010.x. hdl:2027.42/65484. PMID 7525873. S2CID 17388921.

Besançon R, Latour P, Lara K, et al. (2001). "Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2)". Hum. Mutat. 17 (3): 237. doi:10.1002/humu.11. PMID 11241848. S2CID 33419662.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

v t e PDB gallery
1pmp: CRYSTALLOGRAPHIC STUDIES ON A FAMILY OF CELLULAR LIPOPHILIC TRANSPORT PROTEINS. REFINEMENT OF P2 MYELIN PROTEIN AND THE STRUCTURE DETERMINATION AND REFINEMENT OF CELLULAR RETINOL-BINDING PROTEIN IN COMPLEX WITH ALL-TRANS-RETINOL

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

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