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(Top) 1 Interactions 2 References 3 Further reading

POLE3

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POLE3

Identifiers

Aliases

POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2

External IDs

OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q32	Start	113,407,235 bp^[1]
Band	9q32	End	113,410,675 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 B3	Start	62,440,886 bp^[2]
Band	4\|4 B3	End	62,443,305 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

gastrocnemius muscle

granulocyte

monocyte

human penis

ganglionic eminence

muscle of thigh

rectum

ventricular zone

bone marrow

Top expressed in

spermatocyte

ventricular zone

yolk sac

secondary oocyte

zygote

fetal liver hematopoietic progenitor cell

seminiferous tubule

morula

molar

mandibular prominence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity histone acetyltransferase activity
Cellular component	epsilon DNA polymerase complex nucleus nucleoplasm
Biological process	DNA replication histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle cellular response to DNA damage stimulus CENP-A containing chromatin assembly cellular response to gamma radiation DNA replication initiation telomere maintenance via semi-conservative replication
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54107


59001

Ensembl


ENSG00000148229


ENSMUSG00000028394

UniProt


Q9NRF9


Q9JKP7

RefSeq (mRNA)


NM_001278255 NM_017443


NM_021498

RefSeq (protein)


NP_001265184 NP_059139


NP_067473

Location (UCSC)

Chr 9: 113.41 – 113.41 Mb

Chr 4: 62.44 – 62.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.^[5]^[6]^[7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[7]

Interactions

[edit]

POLE3 has been shown to interact with SMARCA5.^[6]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

^ ^a ^b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.

^ ^a ^b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

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