Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

Search

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

Contents

(Top) 1 References

PPADS

●Српски / srpski ●Srpskohrvatski / српскохрватски Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

PPADS
Names

IUPAC name 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzene-1,3-disulfonic acid
Other names PPADS
Identifiers
CAS Number	149017-66-3^Y 192575-19-2 (tetrasodium salt)^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:34941^Y
ChemSpider	20136164
PubChem CID	6093163 6532796 (tetrasodium salt)
UNII	L6K2LJ9BJK^Y
InChI InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)/b17-16+
SMILES Oc2c(C=O)c(COP(O)(=O)O)c(/N=N/c1ccc(cc1S(O)(=O)=O)S(O)(=O)=O)nc2C
Properties
Chemical formula	C₁₄H₁₄N₃O₁₂PS₂
Molar mass	511.37 g·mol⁻¹
Appearance	Orange solid
Solubility in water	100 mM (tetrasodium salt)^[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.^[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α₁ adrenergic, muscarinic M₂ and M₃, histamine H₁, and adenosine A₁ receptors.^[3]

References

[edit]

^ PPADS tetrasodium salt, Santa Cruz Biotechnology

^ Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839. PMID 8306091.

^ Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217 (2–3): 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.

t

e

Purine receptor modulators

Receptor
(ligands)

Agonists: 8-Aminoadenine
Adenine

P2
(nucleotide)

Transporter
(blockers)

Decynium-22

Enzyme
(inhibitors)

Others

Others

Others: Chrysophanol (rhubarb)

See also: Receptor/signaling modulators

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

t

e

Retrieved from "https://en.wikipedia.org/w/index.php?title=PPADS&oldid=1077171271" Categories: ●Azo compounds ●Organophosphates ●Pyridines ●Sulfonic acids ●Genito-urinary system drug stubs Hidden categories: ●Chemical articles with multiple compound IDs ●Multiple chemicals in an infobox that need indexing ●Chemical articles with multiple CAS registry numbers ●Chemical articles with multiple PubChem CIDs ●Articles without KEGG source ●Articles containing unverified chemical infoboxes ●Chembox image size set ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 14 March 2022, at 21:46 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view