Contents

PPP1CA

Enzyme

PPP1CA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E7A, 3E7B, 3EGG, 3EGH, 3HVQ, 3N5U, 3V4Y, 4G9J, 4MOV, 4MOY, 4MP0, 4XPN, 1FJM
Identifiers
Aliases	PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A, protein phosphatase 1 catalytic subunit alpha
External IDs	OMIM: 176875; MGI: 103016; HomoloGene: 105262; GeneCards: PPP1CA; OMA:PPP1CA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,398,181 bp[1] End 67,421,183 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,242,064 bp[2] End 4,245,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon monocyte spleen thymus apex of heart blood lymph node mucosa of pharynx human penis Top expressed in striatum of neuraxis tail of embryo granulocyte yolk sac neural tube thymus mesencephalon white adipose tissue epiblast olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding protein binding hydrolase activity cadherin binding involved in cell-cell adhesion protein serine/threonine phosphatase activity phosphatase activity protein phosphatase 1 binding ribonucleoprotein complex binding protein-containing complex binding Cellular component cytoplasm plasma membrane nucleoplasm PTW/PP1 phosphatase complex nucleolus extracellular exosome nucleus cytosol protein phosphatase type 1 complex glycogen granule neuron projection neuronal cell body dendritic spine perikaryon presynapse postsynapse glutamatergic synapse Biological process regulation of canonical Wnt signaling pathway negative regulation of protein binding cell division glycogen metabolic process cell cycle regulation of translational initiation by eIF2 alpha dephosphorylation beta-catenin destruction complex disassembly dephosphorylation cell-cell adhesion protein dephosphorylation circadian regulation of gene expression regulation of circadian rhythm entrainment of circadian clock by photoperiod carbohydrate metabolic process regulation of glycogen biosynthetic process regulation of glycogen catabolic process response to lead ion lung development peptidyl-threonine dephosphorylation branching morphogenesis of an epithelial tube peptidyl-serine dephosphorylation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5499 19045 Ensembl ENSG00000172531 ENSMUSG00000040385 UniProt P62136 P62137 RefSeq (mRNA) NM_206873 NM_001008709 NM_002708 NM_031868 RefSeq (protein) NP_001008709 NP_002699 NP_996756 NP_114074 Location (UCSC) Chr 11: 67.4 – 67.42 Mb Chr 19: 4.24 – 4.25 Mb PubMed search [3] [4]
Wikidata
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Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Function[edit]

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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Interactions[edit]

PPP1CA has been shown to interact with:

References[edit]

Further reading[edit]