Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene.[5] In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).[6]
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.[7]
PPP2R1A has been shown to interact with:
RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.
|
PDB gallery
| |
|---|---|
1b3u: CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
2iae: Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
2ie3: Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
2ie4: Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
2npp: Structure of the Protein Phosphatase 2A Holoenzyme
2nyl: Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
2nym: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
2pkg: Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40
|
